Summary
Calves experimentally infected with bovine rhinovirus type 1 developed a mild respiratory disease and exhibited a cell mediated immune (CMI) response, as determined by leukocyte migration inhibition (LMI) and lymphocyte blastogenesis tests. The CMI response to the virus was detected by day 3 post-inoculation using direct and indirect LMI tests. It persisted through day 28, with maximal responses occurring between days 4 and 14. Measurement of cellular immunity by blast transformation, however, was not evidenced until day 12. The humoral antibody response was minimal with serum neutralizing titers ranging from 1:4 to 1:16 and this response was not evident until 3 weeks after inoculation.
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Approved as Scientific Article No. A 2462; Contribution No. 5491 from the Maryland Agricultural Experiment Station. — We thank Dr. J. L. McCoy, National Institutes of Health, Bethesda, Maryland, and Dr. E. H. Stephenson, Walter Reed Army Institute of Research, Washington, D.C., for their advice.
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Hussain, A., Mohanty, S.B. Cell mediated immunity to bovine rhinovirus type 1 in calves. Archives of Virology 59, 17–24 (1979). https://doi.org/10.1007/BF01317890
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DOI: https://doi.org/10.1007/BF01317890