Summary
Differences in the pathogenesis of porcine parvovirus (PPV) were shown when pregnant gilts were infected by the oral and intramuscular (i.m.) routes.
By the oral route, PPV took 23–32 days to cross the placenta following infection of the dam, as compared to 15 days by the i.m. route. Successful transplacental infection occurred following oral infection of dams only in the second third of gestation, whilst i.m. infection resulted in infection of foetuses in both first and second thirds of gestation.
Foetal infection resulted in death and mummification only where infection of foetuses occurred before onset of immune competence—estimated at 70 days gestation. Infected foetuses either died before onset of immune competence, or survived to mount an immune response with subsequent death or survival to farrowing.
It is suggested in discussion that reproductive failure due to PPV, characterised by mummification or occasional stillbirth, is associated in nature with oral infection, and occurs only when dams are infected in the first part of the midthird of gestation.
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References
Cartwright, S. F., Huck, R. A.: Virus isolated in association with herd infertility, abortion and stillbirth in pigs. Vet. Rec.81, 196–197 (1967).
Cartwright, S. F., Lucas, M., Huck, R. A.: A small haemagglutinating porcine DNA virus. II. Biological and Serological studies. J. comp. Pathol.81, 144–155 (1971).
Donaldson-Wood, C. R., Joo, H. S., Johnson, R. H.: The effect on reproductive performance of porcine parvovirus infection in a susceptible pig herd. Vet. Rec. in press (1976).
Evans, H. E., Sack, W. O.: Prenatal development of domestic and laboratory mammals; Growth curves, external features and selected references. Zbl. vet. Med.2 C, 11–45 (1973).
Johnson, R. H., Collings, D. F.: Transplacental infection of piglets with a porcine parvovirus. Res. vet. Sci.12, 570–572 (1971).
Johnson, R. H.: Isolation of swine parvovirus in Queensland. Aust. vet. J.49, 157–159 (1973).
Johnson, R. H., Donaldson-Wood, C. R., Joo, H. S., Allender, U.: Observations on the epidemiology of porcine parvovirus. Aust. vet. J.52, 80–84 (1976).
Joo, H. S., Donaldson-Wood, C. R., Johnson, R. H.: A microneutralization test for the assay of porcine parvovirus antibody. Arch. Virol.47, 337–431 (1975).
Joo, H. S., Donaldson-Wood, C. R., Johnson, R. H.: Rapid diagnostic techniques for detection of porcine parvovirus infection in mummified foetuses. Aust. vet. J.52, 51–52 (1976).
Mengeling, W. L., Cutlip, R. C., Wilson, R. A., Parks, J. B., Marshall, R. F.: Foetal mummification associated with porcine parvovirus infection. J. amer. vet. Med. Ass.166, 993–995 (1975).
Morimoto, T., Kurogi, H., Miura, Y., Sugimori, T., Fujisaki, Y.: Isolation of Japanese encephalitis virus and a haemagglutinating DNA virus from the brain of stillborn piglets. Nat. Inst. anim. Hlth. Quart.12, 127–136 (1972).
Rodeffer, H. E., Leman, A. D., Dunne, H. W., Cropper, M., Sprecher, D. J.: Reproductive failure in swine associated with maternal seroconversion for porcine parvovirus. J. amer. vet. Med. Ass.166, 991–992 (1975).
Rondhuis, P. R., Straver, P. J.: Some properties of a small haemagglutinating DNA-virus, isolated from an aborted porcine foetus. Tijdschrift voor Diergeneeskunde97, 1257–1267 (1972).
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Joo, H.S., Donaldson-Wood, C.R. & Johnson, R.H. Observations on the pathogenesis of porcine parvovirus infection. Archives of Virology 51, 123–129 (1976). https://doi.org/10.1007/BF01317841
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DOI: https://doi.org/10.1007/BF01317841