Skip to main content
Log in

Cytogenetic analysis of the sensitivity to anti-viral and anti-cell growth activities of human fibroblast interferon in aneuploid human tumor cell lines

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

The ability of human fibroblast interferon to suppress colony formation and papovavirus T-antigen expression in six human tumor cell lines did not appear to correlate with their content of chromosomes 16 and 21. Additional factors or chromosomes may be involved in the manifestation of interferon action in aneuploid cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Balkwill, F. R., Oliver, T. D.: Growth inhibitory effects of interferon on normal and malignant human hematopoietic cells. Int. J. Cancer20, 500–505 (1977).

    Google Scholar 

  2. Caspersson, T., Lomakka, G., Zech, L.: Twenty-four fluorescence patterns of human metaphase chromosomes. Hereditas67, 89–102 (1971).

    Google Scholar 

  3. Chany, C., Vignal, M., Couillin, P., Cong, N. V., Boue, A.: Chromosomal localization of human genes governing the interferon-induced antiviral state. Proc. Nat. Acad. Sci. U.S.A.72, 3129–3133 (1975).

    Google Scholar 

  4. Cupples, C. G., Tan, Y. H.: Effect of human interferon preparations on lymphoblastogenesis in Down's syndrome. Nature267, 165–167 (1977).

    Google Scholar 

  5. Giard, D. J., Aaronson, S. A., Todaro, G. J., Arnstein, P., Kersey, J. H., Dosik, H., Parks, W. P.:In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors. J. nat. Cancer Inst.51, 1417–1423 (1973).

    Google Scholar 

  6. Gresser, I., Bourali, C.: Anti-tumor effects of interferon preparation in mice. J. nat. Cancer Inst.45, 365–374 (1970).

    Google Scholar 

  7. Kaplan, M. M., Lubiniecki, A. S., Blattner, W. A., Mason, T., Giard, D. J., Gunnell, M., Triantafell, N., Fraumeni, J. F.: Systematic variables affecting minimal virus 40-induced T-antigen expression and transformation in human cells. J. clin. Microbiol.3, 593–598 (1976).

    Google Scholar 

  8. Lee, S. H. S., O'Shaughnessy, M. V., Rozee, K. R.: Interferon induced growth depression in diploid and heteroploid human cells. Proc. Soc. exp. Biol. Med.139, 1438–1440 (1972).

    Google Scholar 

  9. Lubiniecki, A. S., Blattner, W. A., Cruttenden, V., Gunnell, M., Tarr, G. C., Fraumeni, J. F.: T-antigen expression in human skin fibroblast is not regulated by an endogenous interferon response to SV 40 infection. Arch. Virol.57, 349–354 (1978).

    Google Scholar 

  10. Lubiniecki, A. S., Costa, J., Rabson, A. S.: Elevated expression of T-antigen in skin fibroblast from individuals with cytogenetic anomalies infectedin vitro with simian or human papovaviruses. Proc. Soc. exp. Biol. Med.154, 505–507 (1977).

    Google Scholar 

  11. Revel, M., Bash, D., Ruddle, F. H.: Antibodies to a cell surface component coded by human chromosome 21 inhibit action of interferon. Nature260, 139–141 (1976).

    Google Scholar 

  12. Rowley, J. D., Potter, D.: Chromosome banding patterns in acute non-lymphocytic leukemia. Blood47, 705–721 (1976).

    Google Scholar 

  13. Smith, H. S., Owens, R. B., Hiller, A. J., Nelson-Rees, W., Johnston, J. O.: The biology of human cells in tissue culture. I. Characterization of cells derived from osteogenic sarcomas. Int. J. Cancer17, 219–234 (1976).

    Google Scholar 

  14. Strander, H., Cantell, K., Jakobsson, P. A., Nilsonne, U., Soderberg, G.: Exogenous interferon therapy of osteogenic sarcoma. Act. Orthop. Scand.45, 958 (1974).

    Google Scholar 

  15. Sun, N. C., Chu, E. H. U., Cheng, C. C.: Staining method for the banding patterns of human mitotic chromosomes. Caryologia27, 215–224 (1974).

    Google Scholar 

  16. Tan, Y. H.: Chromosome 21 and the cell growth inhibitory effect of human interferon preparations. Nature260, 141–143 (1976).

    Google Scholar 

  17. Tan, Y. H., Tischfield, J., Ruddle, F. H.: The linkage of genes for the human interferon-induced antiviral protein and indophenol oxidase-B traits to chromosome G-21. J. exp. Med.137, 317–330 (1973).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

With 3 Figures

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lubiniecki, A.S., Jones, V. & Eatherly, C. Cytogenetic analysis of the sensitivity to anti-viral and anti-cell growth activities of human fibroblast interferon in aneuploid human tumor cell lines. Archives of Virology 60, 341–346 (1979). https://doi.org/10.1007/BF01317505

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01317505

Keywords

Navigation