Summary
The ability of human fibroblast interferon to suppress colony formation and papovavirus T-antigen expression in six human tumor cell lines did not appear to correlate with their content of chromosomes 16 and 21. Additional factors or chromosomes may be involved in the manifestation of interferon action in aneuploid cells.
References
Balkwill, F. R., Oliver, T. D.: Growth inhibitory effects of interferon on normal and malignant human hematopoietic cells. Int. J. Cancer20, 500–505 (1977).
Caspersson, T., Lomakka, G., Zech, L.: Twenty-four fluorescence patterns of human metaphase chromosomes. Hereditas67, 89–102 (1971).
Chany, C., Vignal, M., Couillin, P., Cong, N. V., Boue, A.: Chromosomal localization of human genes governing the interferon-induced antiviral state. Proc. Nat. Acad. Sci. U.S.A.72, 3129–3133 (1975).
Cupples, C. G., Tan, Y. H.: Effect of human interferon preparations on lymphoblastogenesis in Down's syndrome. Nature267, 165–167 (1977).
Giard, D. J., Aaronson, S. A., Todaro, G. J., Arnstein, P., Kersey, J. H., Dosik, H., Parks, W. P.:In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors. J. nat. Cancer Inst.51, 1417–1423 (1973).
Gresser, I., Bourali, C.: Anti-tumor effects of interferon preparation in mice. J. nat. Cancer Inst.45, 365–374 (1970).
Kaplan, M. M., Lubiniecki, A. S., Blattner, W. A., Mason, T., Giard, D. J., Gunnell, M., Triantafell, N., Fraumeni, J. F.: Systematic variables affecting minimal virus 40-induced T-antigen expression and transformation in human cells. J. clin. Microbiol.3, 593–598 (1976).
Lee, S. H. S., O'Shaughnessy, M. V., Rozee, K. R.: Interferon induced growth depression in diploid and heteroploid human cells. Proc. Soc. exp. Biol. Med.139, 1438–1440 (1972).
Lubiniecki, A. S., Blattner, W. A., Cruttenden, V., Gunnell, M., Tarr, G. C., Fraumeni, J. F.: T-antigen expression in human skin fibroblast is not regulated by an endogenous interferon response to SV 40 infection. Arch. Virol.57, 349–354 (1978).
Lubiniecki, A. S., Costa, J., Rabson, A. S.: Elevated expression of T-antigen in skin fibroblast from individuals with cytogenetic anomalies infectedin vitro with simian or human papovaviruses. Proc. Soc. exp. Biol. Med.154, 505–507 (1977).
Revel, M., Bash, D., Ruddle, F. H.: Antibodies to a cell surface component coded by human chromosome 21 inhibit action of interferon. Nature260, 139–141 (1976).
Rowley, J. D., Potter, D.: Chromosome banding patterns in acute non-lymphocytic leukemia. Blood47, 705–721 (1976).
Smith, H. S., Owens, R. B., Hiller, A. J., Nelson-Rees, W., Johnston, J. O.: The biology of human cells in tissue culture. I. Characterization of cells derived from osteogenic sarcomas. Int. J. Cancer17, 219–234 (1976).
Strander, H., Cantell, K., Jakobsson, P. A., Nilsonne, U., Soderberg, G.: Exogenous interferon therapy of osteogenic sarcoma. Act. Orthop. Scand.45, 958 (1974).
Sun, N. C., Chu, E. H. U., Cheng, C. C.: Staining method for the banding patterns of human mitotic chromosomes. Caryologia27, 215–224 (1974).
Tan, Y. H.: Chromosome 21 and the cell growth inhibitory effect of human interferon preparations. Nature260, 141–143 (1976).
Tan, Y. H., Tischfield, J., Ruddle, F. H.: The linkage of genes for the human interferon-induced antiviral protein and indophenol oxidase-B traits to chromosome G-21. J. exp. Med.137, 317–330 (1973).
Author information
Authors and Affiliations
Additional information
With 3 Figures
Rights and permissions
About this article
Cite this article
Lubiniecki, A.S., Jones, V. & Eatherly, C. Cytogenetic analysis of the sensitivity to anti-viral and anti-cell growth activities of human fibroblast interferon in aneuploid human tumor cell lines. Archives of Virology 60, 341–346 (1979). https://doi.org/10.1007/BF01317505
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01317505