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Detection of measles virus antigen(s) in peripheral lymphocytes from patients with subacute sclerosing panencephalitis

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Summary

Peripheral blood lymphocytes from 5 patients with subacute sclerosing panencephalitis (SSPE) were stimulated with phytohemagglutinin (PHA) and analyzed for the presence of the measles virus antigen(s) by immunofluorescence (IF). For detection of viral antigen fluorescein-conjugated globulins from SSPE patients or from measles convalescents both with high anti-measles titer were used. Peripheral blood lymphocytes from 5 children with measles were used as a positive control.

Measles virus antigen(s) were localized in PHA-transformed lymphocytes in all SSPE patients.

The present results indicate that in SSPE measles-like virus infection may be found not only in the central nervous system, but also in the circulating lymphoid cells.

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Authors and Affiliations

  1. Virus Research Laboratory of Immunopathology Department Institute of Infectious and Parasitic Diseases, Medical School in Warsaw, Warsaw, Poland

    H. Wrzos, Z. Laskowski, D. Matacz & W. J. Brzosko

  2. I. Neurologic Clinic, Psychoneurological Institute, Warsaw, Poland

    J. Kulczycki

Authors
  1. H. Wrzos
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  2. J. Kulczycki
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  3. Z. Laskowski
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  4. D. Matacz
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  5. W. J. Brzosko
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Wrzos, H., Kulczycki, J., Laskowski, Z. et al. Detection of measles virus antigen(s) in peripheral lymphocytes from patients with subacute sclerosing panencephalitis. Archives of Virology 60, 291–297 (1979). https://doi.org/10.1007/BF01317500

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  • DOI: https://doi.org/10.1007/BF01317500

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