Skip to main content
Log in

Antigenic variants of Junín virus isolated from infectedCalomys musculinus

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

Junín virus establishes a long-term persistent infection in its natural host,Calomys musculinus. Virus recovered from blood of infected animals from 14 to 61 days p.i. behaved antigenically distinct to parental virus, as shown by cross neutralization assays. The emergence of antigenic viral variants occurs during both the acute and persistent state of infection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Ahmed, R., Salmi, A., Butler, L. D., Chiller, J. M., Oldstone, M. B. A.: Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. J. Exp. Med.60, 521–540 (1984).

    Google Scholar 

  2. Coulombié, F. C., Laguens, R. M., Coto, C. E.: Administration of antithymocyte serum modifies the response ofCalomys musculinus to Junín virus infection. Intervirology (in press).

  3. Damonte, E. B., Coto, C. E.: Temperature sensitivity of the arenavirus Junín isolated from persistently infected Vero cells. IntervirologyII, 282–287 (1979).

    Google Scholar 

  4. Guerrero, L. B. de, Weissenbacher, M., Parodi, A. S.: Inmunización contra la fiebre hemorrágica argentina con una cepa atenuada del virus Junín. Medicina (Buenos Aires)29, 1–5 (1969).

    Google Scholar 

  5. Holland, J., Spindler, K., Horodyski, F., Grabau, E., Nichol, S., Van de Pol, S.: Rapid evolution of RNA genomes. Science215, 1577–1585 (1982).

    Google Scholar 

  6. Laguens, R. M., Lampuri, J. S., Coto, C. E., Laguens, R. P.: Patología de la infección persistente delCalomys musculinus con una cepa atenuada de virus Junín. Medicina (Buenos Aires)42, 273–278 (1982).

    Google Scholar 

  7. Lampuri, J. S., Coto, C. E.: Responsabilidad de las variantes serológicas en la infección crónica con virus Junín. Medicina (Buenos Aires)43, 733 (1983).

    Google Scholar 

  8. Lampuri, J. S., Vidal, M. C., Coto, C. E.: Respuesta delCalomys musculinus a la infección experimental con virus Junín. Medicina (Buenos Aires)42, 61–66 (1982).

    Google Scholar 

  9. Lutley, R., Pétursson, G., Pálsson, P. P., Georgsson, G., Klein, J., Nathanson, N.: Antigenic drift in Visna virus: virus variation during long-term infection of Icelandic sheep. J. gen. Virol.64, 1433–1440 (1983).

    Google Scholar 

  10. Narayan, O., Griffin, D., Clements, J.: Virus mutation during ‘slow infection’: temporal development and characterization of mutants of Visna virus recovered from sheep. J. gen. Virol.41, 343–352 (1978).

    Google Scholar 

  11. Oxford, J. S., Hiyam, Abbo, Corcoran, T., Webster, R. G., Smith, A. J., Grilli, E. A., Schild, G. C.: Antigenic and biochemical analysis of field isolates of Influenza B virus: evidence for intra- and inter-epidemic variation. J. gen. Virol.64, 2367–2377 (1983).

    Google Scholar 

  12. Palese, P., Young, J. F.: Variation of Influenza A, B and C viruses. Science215, 1468–1474 (1982).

    Google Scholar 

  13. Portner, A., Webster, R. G., Bean, W. J.: Similar frequencies of antigenic variants in Sendai, Vesicular Stomatitis and Influenza A viruses. Virology104, 235–238 (1980).

    Google Scholar 

  14. Ter Meulen, V., Hall, W. W.: Slow virus infections of the nervous system: virological, immunological and pathogenetic considerations. J. gen. Virol.41, 1–25 (1978).

    Google Scholar 

  15. Webster, R. G., Laver, W. G., Air, G. M., Schild, G. C.: Molecular mechanisms of variation in influenza viruses. Nature296, 115–121 (1982).

    Google Scholar 

  16. Wiktor, T., Koprowski, H.: Antigenic variants of rabies virus. J. Exp. Med.152, 99–112 (1980).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

With 1 Figure

Rights and permissions

Reprints and permissions

About this article

Cite this article

Alché, L.E., Coto, C.E. Antigenic variants of Junín virus isolated from infectedCalomys musculinus . Archives of Virology 90, 343–348 (1986). https://doi.org/10.1007/BF01317382

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01317382

Keywords

Navigation