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Glycoprotein-specific immune response in canine herpesvirus infection

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Summary

Sera from dogs which were infected with canine herpesvirus (CHV) were analyzed for their serological reactivities against virus-specific glycoproteins (gps). By sequential immunoblot analysis using sera from experimentally infected dogs, it was found that the antibody response to gp 145/112 appeared first followed by responses to gp 47 and gp 80. In addition, all sera from naturally infected dogs which showed neutralizing activity to CHV reacted with gp 145/112, whereas 77% and 70% reacted with gp 47 and gp 80, respectively. Furthermore, some of the sera also cross-neutralized feline herpesvirus type 1 (FHV-1) and reacted with gp 143/108 of FHV-1, indicating that gp 145/112 of CHV induced cross-neutralizing antibody response to FHV-1.

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Authors and Affiliations

  1. Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

    X. Xuan, T. Horimoto, J. A. Limcumpao, Y. Tohya, E. Takahashi & T. Mikami

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  1. X. Xuan
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  2. T. Horimoto
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  3. J. A. Limcumpao
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  4. Y. Tohya
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  5. E. Takahashi
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  6. T. Mikami
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Xuan, X., Horimoto, T., Limcumpao, J.A. et al. Glycoprotein-specific immune response in canine herpesvirus infection. Archives of Virology 122, 359–365 (1992). https://doi.org/10.1007/BF01317197

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  • DOI: https://doi.org/10.1007/BF01317197

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