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Possibility of reinfection after immunisation with RA 27/3 live attenuated rubella virus

Archives of Virology volume 129, pages 337–340 (1993)Cite this article

Summary

A serological study was carried out on 527 girls immunized with RA 27/3 rubella vaccine. Data from all scheduled serum samples over a 5-year follow-up were available for 102 vaccinees, 10 (9.8%) of whom showed evidence of reinfection during the 5th year after immunisation, a year in which there was a rubella outbreak in the Siena area (Italy). We examined in greater detail the serological responses of these vaccinees after reinfection and the consequent implications pertinent to the duration of the protective immunity.

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References

  1. Cusi MG, Rossolini GM, Valensin PE, Cellesi C, Zanchi A (1990) Serological evidence of reinfection among vaccinees during rubella outbreak. Lancet 336: 1071

    Google Scholar 

  2. Cusi MG, Rossolini GM, Cellesi C, Valensin PE (1988) Antibody response to wild rubella virus structural proteins following immunization with RA 27/3 live attenuated vaccine. Arch Virol 101: 25–33

    Google Scholar 

  3. Cusi MG, Metelli R, Valensin PE (1989) Immune response to wild and vaccine rubella viruses after rubella vaccination. Arch Virol 106: 63–72

    Google Scholar 

  4. Plotkin SA, Farqhar JD, Ogra PL (1973) Immunologic properties of RA 27/3 rubella virus vaccine. A comparison with strains presently licensed in the United States. JAMA 225: 585–590

    Google Scholar 

  5. O'Shea S, Best JM, Banatvala JE (1984) Persistence of rubella antibody 8–18 years after vaccination. Br Med J 288: 1043–1048

    Google Scholar 

  6. Valensin PE, Rossolini GM, Cusi MG, Zanchi A, Cellesi C, Rossolini A (1987) Specific antibody patterns over a two-year period after rubella immunisation with RA 27/3 live attenutated vaccine. Vaccine 5: 289–294

    Google Scholar 

  7. Forsgren M, Carlstom G, Strangert K (1979) Congenital rubella after maternal reinfection. Scand J Infect Dis 11: 81–83

    Google Scholar 

  8. Green KY, Dorsett PH (1986) Rubella virus antigens: localization of epitopes involved in hemagglutination and neutralization by using monoclonal antibodies. J Virol 57: 893–898

    Google Scholar 

  9. Terry GM, Ho-Terry L, Londesborough P, Rees KR (1988) Localization of the rubella E 1 epitopes. Arch Virol 98: 189–197

    Google Scholar 

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Affiliations

  1. Department of Molecular Biology, Section of Microbiology, University of Siena, Siena, Italy

    Maria G. Cusi & P. E. Valensin

  2. Institute of Infectious Diseases, University of Siena, Siena, Italy

    C. Cellesi

Authors
  1. Maria G. Cusi
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  2. P. E. Valensin
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  3. C. Cellesi
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Cusi, M.G., Valensin, P.E. & Cellesi, C. Possibility of reinfection after immunisation with RA 27/3 live attenuated rubella virus. Archives of Virology 129, 337–340 (1993). https://doi.org/10.1007/BF01316909

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  • DOI: https://doi.org/10.1007/BF01316909

Keywords

  • Infectious Disease
  • Serum Sample
  • Rubella
  • Protective Immunity
  • Serological Study