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Characterization of an antigenic site on glycoprotein 13 (gC) of equid herpesvirus type-1

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Summary

Six monoclonal antibodies directed against EHV-1 glycoprotein 13 were characterized. Five antibodies neutralized EHV-1 and were directed against a single antigenic site which comprised type-specific and type cross-reactive epitopes. Inhibition of monoclonal antibody binding to this site by post-infection equine sera suggests that it is a target of host antibody during natural infection with either EHV-1 or EHV-4.

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Authors and Affiliations

  1. Department of Infectious Diseases, Animals Health Trust, Newmarket, Suffolk, England

    R. Sinclair, B. J. Moult & J. A. Mumford

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  1. R. Sinclair
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  2. B. J. Moult
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  3. J. A. Mumford
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Sinclair, R., Moult, B.J. & Mumford, J.A. Characterization of an antigenic site on glycoprotein 13 (gC) of equid herpesvirus type-1. Archives of Virology 129, 327–336 (1993). https://doi.org/10.1007/BF01316908

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  • DOI: https://doi.org/10.1007/BF01316908

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