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Sulfamethoxazole-induced hepatic injury

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Summary

A patient with several episodes of jaundice associated with sulfamethoxazole therapy is described. In contrast to the histologic picture of hepatocellular necrosis with or without cholestasis that is generally associated with sulfonamide hepatotoxicity, in the present case a relatively pure cholestatic pattern was found. Associated clinical features, as well as the response to drug challenge, were compatible with a hypersensitivity mechanism. The patient's lymphocytes did not undergoin vitro blast transformation upon stimulation with sulfamethoxazole or sulfamethoxazole-containing plasmas.

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Authors and Affiliations

  1. Division of Gastroenterology, Royal Victoria Hospital, Montreal, Canada

    URS P. Steinbrecher MD &  Seymour Mishkin MD

  2. McGill University Clinic, Room M6.02, 687 Pine Avenue West, H3A 1A1, Montreal, Canada

    URS P. Steinbrecher MD &  Seymour Mishkin MD

Authors
  1. URS P. Steinbrecher MD
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  2. Seymour Mishkin MD
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Steinbrecher, U.P., Mishkin, S. Sulfamethoxazole-induced hepatic injury. Digest Dis Sci 26, 756–759 (1981). https://doi.org/10.1007/BF01316868

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  • DOI: https://doi.org/10.1007/BF01316868

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