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Effects of compound U74500A in animal models of gastric and duodenal ulceration

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Abstract

Pretreatment with U74500A (up to 0.65 mg/100 g) failed to affect gastric lesions induced by 100% EtOH gavage in Sprague-Dawley rats. Topical application of U74500A did not reduce lesions induced by 40% EtOH inex vivo gastric chamber preparations. However, pretreatment of rats with U74500A (0.65 g/100 gper os) reduced the incidence and severity of experimental duodenal ulcer induced by cysteamine HCl, and duodenal ulcer induced by cysteamine-HCl plus GABA. These results show U74500A to have powerful and specific antiduodenal ulcer actions. Pharmacologic analysis of organ-bath preparations of the small intestine show this compound to reduce intestinal contractility to applied cholinergic and serotonergic agonists. However, relaxations induced by electrical or nicotinic ganglionic stimulation were unaffected. U74500A itself caused concentrationdependent contractions.

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Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine, University of Ottawa, 451 Smyth Rd., K1H 8M5, Ottawa, Canada

    A. Krantis PhD, R. K. Harding PhD, A. E. McKay BSc(Hons) & G. P. Morris PhD

  2. Department of Medicine, Digestive Diseases Research Group, University of Ottawa, Ottawa, Canada

    A. Krantis PhD, R. K. Harding PhD, A. E. McKay BSc(Hons) & G. P. Morris PhD

  3. Department of Biology, Queen's University, Kingston, Canada

    A. Krantis PhD, R. K. Harding PhD, A. E. McKay BSc(Hons) & G. P. Morris PhD

Authors
  1. A. Krantis PhD
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  2. R. K. Harding PhD
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  3. A. E. McKay BSc(Hons)
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  4. G. P. Morris PhD
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Krantis, A., Harding, R.K., McKay, A.E. et al. Effects of compound U74500A in animal models of gastric and duodenal ulceration. Digest Dis Sci 38, 722–729 (1993). https://doi.org/10.1007/BF01316806

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  • DOI: https://doi.org/10.1007/BF01316806

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