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Treatment of chronic hepatitis C with high-dose interferon α-2b

A multicenter study

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A comparative study of three different high-dose regimens of interferon-α-2b (IFN) was conducted in patients with chronic hepatitis C to determine which was better at obtaining a sustained remission. A total of 126 patients were assigned randomly to one of three groups: group A was given 10 million international units (MIU) of IFN six times a week for eight weeks; group B was given 10 MIU IFN six times a week for four weeks followed by three times a week for an additional eight weeks; group C was given 10 MIU IFN six times a week for two weeks followed by three times a week for 12 weeks. The total dose administered to each group was 480 MIU/patient. Only the dosing schedule varied among the three groups. Among 98 efficacy-evaluable patients, a sustained alanine aminotransferase (ALT) response, defined as persistent normalization of the ALT for greater than six months after the termination of treatment, was achieved in 21.2% (7/33) of group A, 42.3% (11/26) of group B, and 54.5% (18/33) of group C patients. Similarly, a sustained loss of measurable serum hepatitis C virus RNA was observed in 28.6% (8/28) of group A, 40.9% (9/22) of group B, and 48.3% (14/29) of group C patients. Based upon these data, it can be concluded that 10 MIU of IFN administered six days a week for two weeks followed by three times a week for an additional 12 weeks produces the highest rate of both biochemical and virological responses to IFN therapy in patients with chronic HCV.

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  1. Hoofnagle JH, Mullen KD, Jones DB, et al.: Treatment of chronic non-A, non-B hepatitis with recombinant human alpha interferon. N Engl J Med 315:1575–1578, 1986

    Google Scholar 

  2. Davis GL, Balart LA, Schiff ER, et al: Treatment of chronic hepatitis C with recombinant interferon alfa: A multicenter randomized, controlled trial. N Engl J Med 321:1501–1506, 1989

    Google Scholar 

  3. DiBisceglie AM, Martin P, Kassianides C, et al: Recombinant interferon alfa therapy for chronic hepatitis C: A randomized, double-blind, placebo-controlled trial. N Engl J Med 321:1506–1510, 1989

    Google Scholar 

  4. Kuo G, Choo QL, Alter HJ, et al: An assay for circulating antibodies to a major etiologic virus of human non-a, non-B chronic hepatitis. Science 244:362–364, 1989

    Google Scholar 

  5. Van der Poel CL, Cuypers HTM, Rees'nk HW, et al.: Confirmation of hepatitis C virus infection by new four-antigen recombinant immunoblot assay. Lancet 337:317–319, 1991

    Google Scholar 

  6. Yousefi S, Escober MR, Gouldin CW: A practical cytopathic effect on dye uptake interferon assay for routine use in the clinical laboratory. Am J Clin Pathol 83:736–740, 1984

    Google Scholar 

  7. Shindo M, Okuno T, Matsumoto M, et al: Serum 2′, 5′-oligoadenylate synthetase activity during interferon treatment of chronic hepatitis B. Hepatology 8:366–370, 1988

    Google Scholar 

  8. Okamoto H, Okada S, Sugiyama Y, et al.: Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5′-noncoding region. Jpn J Exp Med 60:215–222, 1990

    Google Scholar 

  9. Fujioka S, Hino K, Yasuda S, et al.: Interferon treatment in chronic non-A, non-B, hepatitis.In Viral Hepatitis C, D, and E. T Shikata, RH Purcell, T Uchida, et al (eds.). Amsterdam, Elsevier Science Publishers BV, 1991, pp 167–170

    Google Scholar 

  10. Hino S, Suzuki H, Yamamoto S, et al: A comparative study of interferon α-2b for the treatment of chronic hepatitis C. Clin Rep 16:409–442, 1992 (in Japanese)

    Google Scholar 

  11. Kakumu S, Arao M, Yoshioka K, et al.: Pilot study of recombinant human α-interferon for chronic non-A, non-B hepatitis. Am J Gastroenterol 84(1):40–45, 1989

    Google Scholar 

  12. Kakumu S, Arao M, Yoshioka K, et al: Recombinant human α-interferon therapy for chronic non-A, non-B hepatitis: Second report. Am J Gastroenterol 85(6):655–659, 1990

    Google Scholar 

  13. Iino S, Hino K, Kondo T, et al.: Interferon therapy for non-A, non-B chronic hepatitis. Gastroenterol Jpn 26(suppl 3):224–229, 1991

    Google Scholar 

  14. Merigan T, Sikora K, Breeden JH: Preliminary observations on the effect of human leukocyte interferon in non-Hodgkin's lymphoma. N Engl J Med 299:1449, 1978

    Google Scholar 

  15. Hino K, Kondo T, Kaku K, et al.: Biologic effects of IFN in patients with chronic hepatitis B.In Viral Hepatitis and Hepatocellular Carcinoma. J-L Sung, D-S Chen (eds). Hong Kong, Excerpta Medica, 1990; pp 345–354

    Google Scholar 

  16. Freund M, Von Wussow P, Diedrich H, Eisert R, Link H, Wilke H, Buchholz F, LeBlanc S, Fonatsch C, Deicher H, Poliwoka H: Recombinant human interferon (IFN) alpha-2b in chronic myelogenous leukaemia: dose dependence of response and frequency of neutralizing anti-interferon antibodies. Brit J Haematol 72:350–356, 1989

    Google Scholar 

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Iino, S., Hino, K., Kuroki, T. et al. Treatment of chronic hepatitis C with high-dose interferon α-2b. Digest Dis Sci 38, 612–618 (1993).

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