Summary
When peripheral blood mononuclear cells from HIV-1 seropositive patients were treated with rIL-2 in vitro a rapid increase of 2–12 fold in production of extracellular infectious HIV-1 occurred, in 6 of 9 experiments. Over-all, the increase in the 9 experiments was significant (p<0.01) and provides more direct evidence for an enhancing role of IL-2 in naturally infected cells.
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References
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Todd, B., Pope, J.H. & Georghiou, P. Interleukin-2 enhances production in 24 hours of infectious human immunodeficiency virus type 1 in vitro by naturally infected mononuclear cells from seropositive donors. Archives of Virology 121, 227–232 (1991). https://doi.org/10.1007/BF01316757
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DOI: https://doi.org/10.1007/BF01316757