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Histological variations of the duodenal mucosa in chronic human pancreatitis

Digestive Diseases and Sciences volume 27, pages 917–922 (1982)Cite this article

Abstract

From 16 volunteers with chronic pancreatitis and 36 healthy subjects duodenal biopsies were taken 15–20 cm beyond the papilla of Vater. Several morphometric parameters were calculated. The main results show: a significant decrease of villous area and height but not of the number of intestinal villi; a significant increase of Paneth cells; and a slight decrease in the number of glandular mitoses. This study suggests in man, a possible relationship between exocrine pancreatic secretion and the intestinal mucosa and a trophic action of pancreatic juice on the proliferation and the differentiation of the intestinal mucosa.

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Author information

Affiliations

  1. Groupe de Recherche de Biologie et Pathologie Digestive, INSERM U 151, CHU Rangueil, 31054, Toulouse Cedex, France

    F. Senegas-Balas PhD, M. J. Bastie, D. Balas PhD, J. Escourrou MD, G. Bommelaer MD, C. Bertrand, Y. Arany & A. Ribet MD

  2. Laboratoire d'Histologie-Embryologie, CHU de Limoges, 87031, Limoges Cedex, France

    F. Senegas-Balas PhD, M. J. Bastie, D. Balas PhD, J. Escourrou MD, G. Bommelaer MD, C. Bertrand, Y. Arany & A. Ribet MD

Authors
  1. F. Senegas-Balas PhD
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  2. M. J. Bastie
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  3. D. Balas PhD
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  4. J. Escourrou MD
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  5. G. Bommelaer MD
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  6. C. Bertrand
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  7. Y. Arany
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  8. A. Ribet MD
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Additional information

These investigations were supported by ATP INSERM No. 78-92.

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Senegas-Balas, F., Bastie, M.J., Balas, D. et al. Histological variations of the duodenal mucosa in chronic human pancreatitis. Digest Dis Sci 27, 917–922 (1982). https://doi.org/10.1007/BF01316576

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  • DOI: https://doi.org/10.1007/BF01316576

Keywords

  • Public Health
  • Pancreatitis
  • Healthy Subject
  • Chronic Pancreatitis
  • Intestinal Mucosa