Summary
Leakage of glutamic-oxalacetic transaminase was monitored as an indicator of cell damage during a 48- hour period in which maximum virus replication occurred. There was increased leakage of the enzyme from HEp-2 cells infected with highly oncogenic adenovirus type 12. Leakage from cells infected with adenovirus types 18 and 31 (highly oncogenic), types 3,7 and 14 (weakly oncogenic), and types 1, 2 and 5 (nononcogenic) was similar to that from uninfected HEp-2 cells, even after the appearance of advanced virus-induced cytopathology.
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References
Bardell, D., Metcalf, T. G.: Differential release of cellular lactate dehydrogenase during replication of adenovirus types 5 and 12. J. gen. Virol.14, 219–222 (1972).
Bardell, D., Metcalf, T. G.: Beta-glucuronidase response of cells infected with adenovirus types 5 and 12. Infect. Immun.10, 83–87 (1974).
Guilbault, G. G.: Handbook of Enzymatic Methods of Analysis, 119–121. New York: Marcel Dekker 1976.
Trentin, J. J., Yabe, Y., Taylor, G.: The quest for human cancer viruses. Science137, 835–841 (1962)
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Bardell, D. Leakage of cellular enzyme during replication of oncogenic and nononcogenic adenoviruses. Archives of Virology 76, 69–72 (1983). https://doi.org/10.1007/BF01315705
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DOI: https://doi.org/10.1007/BF01315705