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Effect of cordycepin on the replication of western equine encephalitis virus


Cordycepin (3′-deoxyadenosine) inhibited viral RNA synthesis in the replication of western equine encephalitis virus, thereby causing a reduction of virus production. The rate of inhibition of viral RNA synthesis was dependent on drug concentration and the period of treatment with the drug. These results suggest that the virus RNA synthesizing system is sensitive to the drug.

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  1. 1.

    Darnell, J. E., Philipson, L., Wall, R., Adesnik, M.: Polyadenylic acid sequence: role in conversion of nuclear RNA into messenger RNA. Science174, 507–510 (1971).

    Google Scholar 

  2. 2.

    Dorsch-Hasler, K., Yogo, Y., Wimmer, E.: Replication of picornaviruses. I. evidence fromin vitro RNA synthesis that poly(A) of the poliovirus genome is genetically coded. J. Virol.16, 1512–1527 (1975).

    Google Scholar 

  3. 3.

    Eaton, B. T., Donaghue, T. P., Faulkner, P.: Presence of poly(A) in the polyribosome-associated RNA of Sindbis-infected BHK cells. Nature (London) N. Biol.238, 109–111 (1972).

    Google Scholar 

  4. 4.

    Eaton, B. T., Faulkner, P.: Heterogeneity in the poly(A) content of the genome of Sindbis virus. Virology50, 865–873 (1972).

    Google Scholar 

  5. 5.

    Ehrenfeld, E.: Polyadenylation of vasicular stomatitis virus mRNA. J. Virol.13, 1055–1060 (1974).

    Google Scholar 

  6. 6.

    Hashimoto, K., Suzuki, K., Simizu, B.: Morphological and physical properties of a multiploid-forming mutant of western equine encephalitis virus. J. Virol.15, 1454–1466 (1975).

    Google Scholar 

  7. 7.

    Hashimoto, K., Simizu, B.: Effect of cycloheximide on the replication of western equine encephalitis virus. Japan. J. Med. Sci. Biol.29, 215–219 (1976).

    Google Scholar 

  8. 8.

    Johnston, R. E., Bose, H. R.: Correlation of messenger function with adenylaterich segments in the genomes of single-stranded RNA viruses. Proc. Natl. Acad. Sci. U.S.A.69, 1514–1516 (1972).

    Google Scholar 

  9. 9.

    Mahy, B. W. J., Cox, N. J., Armstrong, S. J., Barry, R. D.: Multiplication of influenza virus in the presence of cordycepin, an inhibitor of cellular RNA synthesis. Nature (London) N. Biol.243, 172–174 (1972).

    Google Scholar 

  10. 10.

    Penman, S., Rosbash, M., Penman, M.: Messenger and heterogeneous nuclear RNA in HeLa cells: differential inhibition by cordycepin. Proc. Natl. Acad. Sci. U.S.A.67, 1878–1885 (1970).

    Google Scholar 

  11. 11.

    Soria, M., Huang, A. S.: Association of polyadenylic acid with messenger RNA of vesicular stomatitis virus. J. mol. Biol.77, 449–455 (1973).

    Google Scholar 

  12. 12.

    Weiss, S. R., Bratt, M. A.: Effect of cordycepin (3′-deoxyadenosine) on virus-specific RNA species synthesized in Newcastle disease virus-infected cells. J. Virol.16, 1575–1583 (1975).

    Google Scholar 

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Hashimoto, K., Simizu, B. Effect of cordycepin on the replication of western equine encephalitis virus. Archives of Virology 52, 341–345 (1976).

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  • Infectious Disease
  • Drug Concentration
  • Encephalitis
  • Virus Production
  • Encephalitis Virus