Summary
Enterovirus serotypes were studied using nucleic acid hybridization and nucleotide sequence analysis. A great majority of enteroviruses could be roughly divided into two larger subgroups the first consisting of poliovirus and certain coxsackievirus A serotypes. The second subgroup included coxsackie B viruses, most ECHO viruses, enterovirus 71 and representatives of coxsackie A viruses. Enterovirus 70 showed low homology to the viruses in both groups. Interestingly, ECHO virus 22 failed to react with any of the hybridization probes indicating a relatively distant relationship. The close relationship between coxsackie B and ECHO viruses as well as between polio and certain coxsackie A viruses was also evident when nucleotide sequences of the 3′ end noncoding parts were compared.
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Auvinen, P., Stanway, G. & Hyypiä, T. Genetic diversity of enterovirus subgroups. Archives of Virology 104, 175–186 (1989). https://doi.org/10.1007/BF01315541
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DOI: https://doi.org/10.1007/BF01315541