Skip to main content
Log in

Inhibitory effect of Virazole (Ribavirin) on the replication of tomato white necrosis virus (VNBT)

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

Tomato plants (Lycopersicon esculentum Mill.) inoculated with tomato white necrosis virus (VNBT) and treated with Virazole (1-beta-D-ribofuranosyl—1, 2, 4-triazole-3-carboxamide) at a concentration of 500 mg/l developed systemic virus symptoms in only 40 per cent of the plants in which a remarkable reduction in virus concentration was also observed. From inoculated and Virazole-treated plants which had produced no symptoms, no virus could be recovered. This result suggests that Virazole may inhibit replication of VNBT in tomato.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Alba, A. P. C., Chagas, C. M., Vicente, Marly, July, J. R., Hebert, T. T.: Partial purification and serology of tomato white necrosis virus. Summa Phytopathologica3, 131–134 (1977).

    Google Scholar 

  2. Chagas, C. M., Vicente, Marly, July, J. R.: Morfologia e características de um vírus causando necrose branca em tomateiro. Arq. Inst. Biol.42, 163–172 (1975).

    Google Scholar 

  3. Khare, G. P., Sidwell, R. W., Witkowski, J. T., Simon, L. N., Robins, R. K.: Supression by 1-beta-D-ribofuranosyl-1-2-4-triazole-3-carboxamide (Virazole ICN 1229) of influenza virus induced infections in mice. Antimicrob. Ag. Chemother.3, 517–522 (1973).

    Google Scholar 

  4. Lerch, B.: Inhibition of biosynthesis of potato virus X by Ribavirin. Phytopath. Z.89, 44–49 (1977).

    Google Scholar 

  5. Oxford, J. S.: Inhibition of the replication of influenza A and B viruses by a nucleoside-analogue (Ribavirin). J. gen. Virol.28, 409–414 (1975).

    Google Scholar 

  6. Scholtissek, C.: Inhibition of influenza RNA synthesis by Virazole (Ribavirin). Arch. Virol.50, 349–352 (1976).

    Google Scholar 

  7. Shepard, J. F.: Regeneration of plants from protoplasts of potato virus X infected tobacco leaves. II. Influence of Virazole on the frequency of infection. Virology78, 261–266 (1977).

    Google Scholar 

  8. Sidwell, R. W., Huffman, J. H., Khare, G. P., Allen, L. B., Witkowski, J. T., Robins, R. K.: Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide. Science177, 705–706 (1972).

    Google Scholar 

  9. Streeter, D. G., Witkowski, J. T., Khare, G. P., Sidwell, R. W., Bauer, R. J., Robins, R. K., Simon, L. N.: Mechanism of action of 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent. Proc. Nat. Acad. Sci. U.S.A.70, 1174–1178 (1973).

    Google Scholar 

  10. Witkowski, J. T., Robins, R. K., Sidwell, R. W., Simon, L. N.: Design synthesis, and broad-spectrum antiviral activity of 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides. J. med. Chem.15, 1150–1154 (1972).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

A Summary of this work was presented at II. Latin American Congress of Botany, Brasilia, January 1978.

Research-fellow of the National Council of Scientific and Technologic Development (CNPq).

Rights and permissions

Reprints and permissions

About this article

Cite this article

de Fazio, G., Caner, J. & Vicente, M. Inhibitory effect of Virazole (Ribavirin) on the replication of tomato white necrosis virus (VNBT). Archives of Virology 58, 153–156 (1978). https://doi.org/10.1007/BF01315408

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01315408

Keywords

Navigation