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Effect of treatment with certain flavonoids on Mengo virus-induced encephalitis in mice

Archives of Virology volume 57, pages 255–260 (1978)Cite this article

Summary

Among the four flavonoids tested quercetin and morin proved to be significantly effective against lethal Mengo virus-induced encephalitis in mice when the drugs were administered orally (p.o.). With subcutaneous (s.c.) administration all four drugs failed to prevent mortality in the infected mice. Quercetin produced maximum protective response in intraperitoneally (i.p.) or intranasally (i.nas.) infected mice when administered twice daily at doses of 20 mg/kg for a period of not less than four days. Single injections of the full daily dose of drug failed to prevent deaths in mice. Treatment must be begun at the time of, or prior to, virus inoculation. Delayed initiation of treatment was ineffective in preventing mortality.

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Authors and Affiliations

  1. Research Centre for Molecular Biology and Medicine, Central Institute for Microbiology and Experimental Therapy, Academy of Sciences of the German Democratic Republic, Jena, German Democratic Republic

    Anneliese Veckenstedt, Ilona Béládi & Ilona Mucsi

  2. Institute of Microbiology, University Medical School of Szeged, Szeged, Hungary

    Anneliese Veckenstedt, Ilona Béládi & Ilona Mucsi

  3. Zentralinstitut für Mikrobiologie und experimentelle Therapie, Beuthenbergstraße 11, DDR-69, Jena, German Democratic Republic

    Anneliese Veckenstedt

Authors
  1. Anneliese Veckenstedt
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  2. Ilona Béládi
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  3. Ilona Mucsi
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Veckenstedt, A., Béládi, I. & Mucsi, I. Effect of treatment with certain flavonoids on Mengo virus-induced encephalitis in mice. Archives of Virology 57, 255–260 (1978). https://doi.org/10.1007/BF01315089

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  • DOI: https://doi.org/10.1007/BF01315089

Keywords

  • Infectious Disease
  • Flavonoid
  • Quercetin
  • Encephalitis
  • Morin

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