Summary
A semicontinuous infection system was used to test viral replication and interferon induction in lymphoblastoid cells: measles virus, Newcastle disease virus (NDV), Sendai virus, human parainfluenza virus (type II and III), Semliki forest virus (SFV) and Vesicular stomatitis virus (VSV). With the exception of Sendai virus, all viruses replicated in the Namalva cell line. Only measles virus was able to induce high levels of interferon. Three other cell lines, NC37, Raji (TK+-variant) and Raji (TK−-variant) were tested using measles virus as inducer. The interferon yields from these cells were inferior to those obtained from Namalva cells.
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References
de Ley, M., Billiau, A., de Somer, P.: A semi-continuous system for the production of human interferon in lymphoblastoid cell cultures. J. gen. Virol.40, 455–458 (1978).
Mellstedt, H., Ahre, A., Björkholm, M., Holm, G., Johansson, B., Strander, H.: Interferon therapy in myelomatosis. The Landeti, 245 (1979).
Strander, H.: Interferons: anti-neoplastic drugs? Blut35, 277–288 (1977).
Strander, H., Mogensen, K. E., Cantell, K.: Production of human lymphoblastoid interferon. J. clin. Microbiol.1, 116–117 (1975).
Tovey, M. G., Begon-Lours, J., Gresser, I., Morris, A. G.: Marked enhancement of interferon production in 5-bromodeoxyuridine treated human lymphoblastoid cells. Nature267, 455–457 (1977).
Volckaert-Vervliet, G., Billiau, A.: Induction of interferon in human lymphoblastoid cells by Sendai and measles virus. J. gen. Virol.37, 199–203 (1977).
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Heremans, H., de Ley, M., Volckaert-Vervliet, G. et al. Interferon production and virus replication in lymphoblastoid cells infected with different viruses. Archives of Virology 63, 317–320 (1980). https://doi.org/10.1007/BF01315039
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DOI: https://doi.org/10.1007/BF01315039