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The 5′ end of foot-and-mouth disease virion RNA contains a protein covalently linked to the nucleotide pUp

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Summary

Foot-and-mouth disease (FMD) virion RNA contains a protein covalently linked to its 5′ end. This protein has a molecular weight of approximately 12,000 daltons and is linked to the nucleotide pUp.

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References

  1. Ambros, V., Baltimore, D.: Protein is linked to the 5′ end of poliovirus RNA by phosphodiester linkage to tyrosine. J. biol. Chem.253, 5263–5266 (1978).

    Google Scholar 

  2. Ambros, V., Pettersson, R. F., Baltimore, D.: An enzymatic activity in uninfected cells that cleaves the linkage between poliovirion RNA and the 5′ terminal protein. Cell15, 1439–1445 (1978).

    Google Scholar 

  3. Ascione, R., Vande Woude, G. F.: Ribosomal factors effecting the stimulation of cell-free protein synthesis in the presence of foot-and-mouth disease virus ribonucleic acid. Biochem. biophys. Res. Commun.45, 12–21 (1971).

    Google Scholar 

  4. Bachrach, H. L., Trautman, R., Breese, S. S., Jr.: Chemical and physical properties of virtually pure foot-and-mouth disease virus. Amer. J. vet. Res.25, 333–342 (1964).

    Google Scholar 

  5. Chatterjee, N. K., Polatnick, J., Bachrach, H. L.: Cell-free translation of foot-and-mouth disease virus RNA into identifiable non-capsid and capsid proteins. J. gen. Virol.32, 383–394 (1976).

    Google Scholar 

  6. Fernandez-Munoz, R., Darnell, J. E.: Structural difference between the 5′ termini of viral and cellular mRNA in poliovirus-infected cells: possible basis for the inhibition of host protein synthesis. J. Virol.18, 719–726 (1976).

    Google Scholar 

  7. Flanegan, J. B., Pettersson, R. F., Ambros, V., Hewlett, M. J., Baltimore, D.: Covalent linkage of a protein to a defined nucleotide sequence at the 5′ terminus of virion and replicative intermediate RNA's of poliovirus. Proc. Nat. Acad. Sci. U.S.A.74, 961–965 (1977).

    Google Scholar 

  8. Golini, R., Nomoto, A., Wimmer, E.: The genome-linked protein of picorna-viruses IV. Differences in the VPg's of encephalomyocarditis virus and poliovirus as evidence that the genome-linked proteins are virus-coded. Virology89, 112–118 (1978).

    Google Scholar 

  9. Grubman, M. J., Bachrach, H. L.: Isolation of foot-and-mouth disease messenger RNA from membrane-bound polyribosomes and characterization of its 5′ and 3′ termini. Virology98, 466–470 (1979).

    Google Scholar 

  10. Grubman, M. J., Baxt, B., Bachrach, H. L.: Foot-and-mouth disease virion RNA: Studies on the relation between the length of its 3′-poly (A) segment and infectivity. Virology97, 22–31 (1979).

    Google Scholar 

  11. Hewlett, M. J., Rose, J. K., Baltimore, D.: 5′-Terminal structure of poliovirus polyribosomal RNA is pUp. Proc. Nat. Acad. Sci. U.S.A.73, 327–330 (1976).

    Google Scholar 

  12. Hruby, D. E., Roberts, W. K.: Encephalomyocarditis virus RNA. III. Presence of a genome-associated protein. J. Virol.25, 413–415 (1978).

    Google Scholar 

  13. Nomoto, A., Detjen, B., Pozzatti, R., Wimmer, E.: The location of the polio genome protein in viral RNAs and its implication for RNA synthesis. Nature (London)268, 208–213 (1977).

    Google Scholar 

  14. Nomoto, A., Lee, Y. F., Wimmer, E.: The 5′ end of poliovirus mRNA is not capped with m7G (5′)ppp(5′) Np. Proc. Nat. Acad. Sci. U.S.A.73, 375–380 (1976).

    Google Scholar 

  15. Perez-Bercoff, R., Gander, M.:In vitro translation of mengovirus RNA deprived of the terminally-linked (capping) protein. FEBS Letters96, 306–312 (1978).

    Google Scholar 

  16. Sangar, D. V., Rowlands, D. J., Harris, T. J. R., Brown, F.: Protein covalently linked to foot-and-mouth disease virus RNA. Nature (London)268, 648–650 (1977).

    Google Scholar 

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Grubman, M.J. The 5′ end of foot-and-mouth disease virion RNA contains a protein covalently linked to the nucleotide pUp. Archives of Virology 63, 311–315 (1980). https://doi.org/10.1007/BF01315038

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  • DOI: https://doi.org/10.1007/BF01315038

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