Summary
Virazole (1, beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide = Ribavirin), a synthetic nucleoside analogue, has been successfully used against tomato spotted wilt virus (TSWV) in tomato and tobacco plants. In tomato, the most efficient concentration to control TSWV was 500 mg/l while in tobacco, concentrations of 100 mg/l were sufficient to control systemic infection. When the plants did not show a systemic reaction virus could not be recovered from inoculated and treated tomato and tobacco plants by means of the local lesion assay. The results point out the response of a new plant virus to Virazole and indicate a possibility of controlling TSWV systemic infection.
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De Fazio, G., Caner, J. & Vicente, M. Effect of Virazole (Ribavirin) on tomato spotted wilt virus in two systemic hosts, tomato and tobacco. Archives of Virology 63, 305–309 (1980). https://doi.org/10.1007/BF01315037
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DOI: https://doi.org/10.1007/BF01315037