Summary
Human leukocyte and mouse fibroblast interferons abolished the mitogenic effect of human or bovine platelet growth factor (PGF) on human or mouse cells. Conversely, the antiviral and anticellular activity of both forms of interferon was inhibited by PGF in the homologous and in certain heterologous cell systems.
This is a preview of subscription content, log in via an institution to check access.
References
Antoniades, H. N., Scher, C. D.: Growth factors derived from human serum, platelets, and pituirary: properties and immunologic cross-reactivity. Nat. Cancer Inst. Monogr.48, 137–140 (1978).
Cembrzynska-Nowak, M.: Studies on the mode of action of IME—an inhibitor of interferon activity from mouse embryo tissues. Arch. Immunol. Ther. Exper.26, 509–512 (1978).
Chany-Fournier, F., Pauloin, A., Chany, C.: Isolation, preliminary determination, and interferon antagonistic effect of a mammalian lectin-like substance. Proc. Nat. Acad. Sci. U.S.A.75, 2333–2337 (1978).
Gresser, I.: On the varied biologic effects of interferon. Cell. Immunol.34, 406–415 (1977).
Gresser, I., Brouty-Boyé, D., Thomas, M. T., Macieira-Coelho, A.: Interferon and cell division. II. Influence of various experimental conditions on the inhibition of L1210 cell multiplicationin vitro by interferon preparations. J. Nat. Cancer Inst.45, 1145–1153 (1970).
Gresser, I., Tovey, M. G.: Antitumor effects of interferon. Biochem. biophys. Acta516, 231–247 (1978).
Gospodarowicz, D., Mescher, A. L., Birdwell, C. L.: Control of cellular proliferation by the fibroblast and epidermal growth factors. Nat. Cancer Inst. Monogr.48, 109–130 (1978).
Grossberg, S. E., Morahan, P. S.: Repression of interferon action: induced dedifferentiation of embryonic cells. Science171, 77–79 (1974).
Inglot, A. D., Kisielow, B., Inglot, O.: Biological properties of mouse interferon bound to a high molecular weight carrier: Blue Dextran 2000. Arch. Virol.60, 43–50 (1979).
Kading, V. H., Blalock, J. E., Gifford, G. E.: Effect of serum on the antiviral and anticellular activities of mouse interferon. Arch. Virol.56, 237–242 (1978).
Ross, R., Glomset, J., Kariya, B., Raines, E.: Role of platelet factors in the growth of cells in culture. Nat. Cancer Inst. Monogr.48, 103–108 (1978).
Rossman, T. G., Vilček, J.: Blocking of interferon action by a component of normal serum. Arch. ges. Virusforseh.31, 18–27 (1970).
Rudland, P. S., Seifert, W., Gospodarowicz, D.: Growth control in cultured mouse fibroblasts: Induction of the pleiotypic and mitogenic responses by a purified growth factor. Proc. Nat. Acad. Sci. U.S.A.71, 2600–2604 (1974).
Sato, G. H.: Growth factors and cellular proliferation. Introductory Remarks. Nat. Cancer Inst. Monogr.48, 77–79 (1978).
Stewart, II W. E., Gresser, I., Tovey, M. G., Bandu, M. T., Legoff, S.: Identification of the cell multiplication inhibitory factors in interferon preparations as interferon. Nature (Lond.)262, 300–302 (1976).
Stewart II, W. E., Chudzio, T., Lin, L. O., Wiranowska-Stewart, M.: Interferoids:In vitro andin vivo conversion of native interferons to lower molecular weight forms. Proc. Nat. Acad. Sci. U.S.A.75, 4814–4818 (1978).
Vilček, J., Lowy, D. R.: Interaction of interferon with chick embryo cells. Arch. ges. Virusforsch.21, 253–264 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Inglot, A.D., Oleszak, E. & Kisielow, B. Antagonism in action between mouse or human interferon and platelet growth factor. Archives of Virology 63, 291–296 (1980). https://doi.org/10.1007/BF01315035
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01315035