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Survival of intracellular pathogens within macrophages

  • Focus on Cellular Biochemistry
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Summary

The threat caused by intracellular pathogens increases as conventional drag treatments are less and less effective against a wide range of microorganisms. Understanding the molecular mechanisms used by intracellular pathogens to avoid killing and degradation in their host cells is likely to point at new ways to threat infectious diseases. We discuss some of the strategies used by various microorganisms to avoid killing and degradation in phagolysosomes. Interestingly, it appears that microbes have a lot to teach us about the cell biology and molecular mechanisms of organelle sorting in macrophages.

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  1. Départment de Pathologie et Biologie Cellulaire, Université de Montréal, succursale Centre Ville, C.P. 6128, H3C 3J7, Montréal, Que., Canada

    Jean -François Dermine & Michel Desjardins

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  1. Jean -François Dermine
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  2. Michel Desjardins
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Dermine, J.F., Desjardins, M. Survival of intracellular pathogens within macrophages. Protoplasma 210, 11–24 (1999). https://doi.org/10.1007/BF01314950

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