, Volume 210, Issue 1–2, pp 1–10 | Cite as

Rab GTPases as regulators of transport through endosomes

  • Peter van der Sluijs
  • Lisya Gerez
Focus on Cellular Biochemistry


Early endocytic compartments are a highly dynamic, heterogeneous class of prelysosomal organelles that receive internalized proteins from the plasma membrane and sort these to various intracellular destinations. Several monomeric Rab GTPases are associated with the cytoplasmic surface of endosomes and regulate the dynamics of this endomembrane system. We discuss the endosomal Rab proteins and their effector proteins and how they might control vesicular transport through the endocytic pathway.


Endocytosis Rab proteins Effectors 


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© Springer-Verlag 1999

Authors and Affiliations

  • Peter van der Sluijs
    • 1
  • Lisya Gerez
    • 1
  1. 1.Department of Cell Biology, AZU Rm H02.314Utrecht University School of MedicineCX UtrechtThe Netherlands

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