Skip to main content

Advertisement

SpringerLink
Log in

The induction of murine cytotoxic T lymphocytes by bluetongue virus

  • Original Papers
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

After inoculation with live bluetongue virus, mice produced cytotoxic T lymphocytes (CTL) which showed virus and H-2 restriction. Inactivated preparations failed to induce CTLs. On secondaryin vitro stimulation, specifically sensitised memory cells also produced high numbers of CTLs. The need for replicating virus to induce primary CTLs, evidence for partial type specificity and the role which cell-mediated immunity might play in the early stages of a bluetongue virus infection are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Allison, A. C.: Interactions of antibodies, complement components and various cell types in immunity against viruses and pyogenic bacteria. Transplant Rev.19, 3–55 (1974).

    Google Scholar 

  2. Blanden, R. V., Gardener, I. D.: The cell mediated immune response to ectromelia virus infection. I. Kinetics and characteristics of the primary effector T cell responsein vivo. Cell. Immunol.22, 271–282 (1976).

    Google Scholar 

  3. Bloom, B. R., Zisman, B. R.: Cell mediated immunity in viral infections, 113–126. In:Notkins, A. L. (ed.), Viral immunology and immunopathology. New York: Academic Press 1975.

    Google Scholar 

  4. Boulanger, P., Frank, J. F.: Serological methods in the diagnosis of bluetongue. Aust. Vet. Journal51, 185–189 (1975).

    Google Scholar 

  5. Braciale, J. T., Yap, K. L.: Role of viral infectivity in the induction of influenza virus specific cytotoxic T cells. J. exp. Med.147, 1236–1252 (1878).

    Google Scholar 

  6. Doherty, P. R. C., Blanden, V., Zinkernagel, R. M.: Specificity of virus immune effector cells for H2K and H2D compatible interaction; implications for H antigen diversity. Transplant Rev.29, 89–124 (1976).

    Google Scholar 

  7. Ertl, H. C., Gerike, R. H. W., Koszinowski, U. H.: Virus specific T cell sensitization requirement for vaccinia virus specific T cell sensitizationin vivo. Immunogenetics4, 415–525 (1977).

    Google Scholar 

  8. Gajdowa, E., Mayer, V., Oravec, C.: Cross reactive Killer T lymphocytes in a flavivirus infection. Acta virol.24, 291–293 (1980).

    Google Scholar 

  9. Gidlund, M., Orn, A., Wigzell, H., Senek, A., Gresser, I.: Enhanced N.K. activity in mice injected with interferon and interferon inducers. Nature273, 759–761 (1978).

    Google Scholar 

  10. Hapel, A. P., Bablanian, R., Cole, G. A.: Inductive requirements for the generation of virus specific interactions that trigger secondary pox virus specific cytotoxic T lymphocytes. J. Immunol.121, 736–743 (1978).

    Google Scholar 

  11. Herberman, R. B., Holden, H. T.: Natural cell mediated immunity. Adv. Cancer Res.27, 305–312 (1978).

    Google Scholar 

  12. Hellstrom, K. E., Hellstrom, I.: Lymphocytes mediated cytotoxicity and blocking serum activity to tumor antigens. Adv. Immunol.18, 209–253 (1974).

    Google Scholar 

  13. Julius, M. H., Simpson, E., Herzenberg, L. A.: A rapid method for the isolation of functional thymus derived murine lymphocytes. Eur. J. Immunol.3, 645–652 (1973).

    Google Scholar 

  14. Kirschner, H. G., Darai, H. M., Hirt, K., Keyssner, K., Munk, K.:In vitro mitogenic stimulation of murine spleen cells by herpes simplex virus. J. Immunol.120, 641–647 (1978).

    Google Scholar 

  15. Lagrance, P. H., Mackaness, G. B., Miller, T. E.: Potentiation of T cell mediated immunity by selective suppression of antibody with cyclophosphamide. J. exp. Med.129, 1529–1534 (1974).

    Google Scholar 

  16. Lawman, M.: Observations on the pathogenesis of bluetongue virus infection in sheep. Ph. D. Thesis, University of Surrey (1979).

  17. Lawman, M., Rouse, B. T., Courtney, R. J., Walker, D. R.: Cell mediated immunity against herpes simplex induction of cytotoxic T lymphocytes. Infect. Immun.127, 133–139 (1980).

    Google Scholar 

  18. Manischewitz, J. E., Quinnan, G. V.: Antivirus antibody dependent cell mediated cytotoxicity during cytomegalovirus infection. Infect. Immun.129, 1050–1054 (1980).

    Google Scholar 

  19. Leudke, A. J., Jochim, M. M.: Clinical and serologic responses in vaccinated sheep given challenge inoculation with isolates of bluetongue virus. Amer. J. Vet. Res.29, 851 (1968).

    Google Scholar 

  20. Oellerman, R. A., Carter, P., Marx, M. J.: Kinetics of the IgM and IgG immunological response to sheep erythrocytes and bluetongue virus in mice. Onderspoort, J. Vet. Res.43, 185–188 (1976).

    Google Scholar 

  21. Paige, C., Figarella, E. F., Cuttito, M. J., Cahan, A., Stutman, O.: Natural cytotoxic cells against solid tumors in mice. II. Some characteristics of the effector cells. J. Immunol.121, 1827–1834 (1978).

    Google Scholar 

  22. Parker, J., Herniman, K. A. J., Gibbs, E. P. J., Sellers, R. F.: An experimental inactivated vaccine against Bluetongue. Vet. Rec.96, 284–287 (1975).

    Google Scholar 

  23. Quinnan, G. V., Manischewitz, J. E., Ennis, F. A.: Cytotoxic T lymphocytes response to murine cytomegalovirus infection. Nature (London)273, 541–543 (1978).

    Google Scholar 

  24. Rinaldo, C. R., Overall, J. C., Glasgow, L. A.: Virus replication and interferon production in foetal and adult ovine leucocytes and spleen cells. Infect. Immun.12, 1070–1077 (1975).

    Google Scholar 

  25. Rodda, S. J., White, D. O.: Cytotoxic macrophages: A rapid non-specific response to viral infection. J. Immunol.117, 2067–2071 (1978).

    Google Scholar 

  26. Rouse, B. T., Lawman, M.: Induction of cytotoxic T lymphocytes against herpes simplex virus type 1—Role of accessory cells and amplifying factor. J. Immunol.124, 2341 (1980).

    Google Scholar 

  27. Scharder, J. W., Edelman, G. M.: Joint recognition by cytotoxic cells of inactivated Sendai virus and products of the major histocompatibility complex. J. exp. Med.145, 523–529 (1977).

    Google Scholar 

  28. Stott, J. L., Osburn, B. I., Barber, T. L., Sawyer, M.: Immunological response of sheep to an experimental inactivated B.T.V. vaccine. J. Amer. Vet. Med. Assoc.175, 611 (1979).

    Google Scholar 

  29. Stutman, O., Paige, C., Figarella, E. F.: Natural cytotoxic cells against solid tumors in mice. I. Strain and age distribution and target cell susceptibility. J. Immunol.121, 1819–1826 (1978).

    Google Scholar 

  30. Trinchieri, G., Santoli, D.: Antiviral activity induced by culturing lymphocytes with tumour derived or virus transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis. J. exp. Med.147, 1214–1333 (1978).

    Google Scholar 

  31. Welsh, R. M.: Mouse natural killer cells. Induction specificity and function. J. Immunol.121, 1631 (1978).

    Google Scholar 

  32. Zinkernagel, R. M., Althage, A.: Antiviral protection by virus immune cytotoxic T cells. Infected target cells are lysed before infectious virus progency is established. J. exp. Med.145, 644–651 (1977).

    Google Scholar 

  33. Zinkernagel, R. M., Welsh, R. M.: H2 compatibility requirement for virus specific T cell mediated effector functionin vivo. Specificity of T cell confirming antiviral protection against lymphocytic choriomeningitis virus is associated with H2K and H2D. J. Immunol.17, 1495–1500 (1976).

    Google Scholar 

  34. Zweerink, H. J., Courtneidge, S. A., Skehel, J. J., Crumpton, M. J., Askonas, B. A.: Cytotoxic T cells kill influenza virus infected cells but do not distinguish between serologically distinct A viruses. Nature267, 354 (1977).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Animal Virus Research Institute, Pirbright, Woking, Surrey, England

    M. H. Jeggo & R. C. Wardley

Authors
  1. M. H. Jeggo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. C. Wardley
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

With 1 Figure

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jeggo, M.H., Wardley, R.C. The induction of murine cytotoxic T lymphocytes by bluetongue virus. Archives of Virology 71, 197–206 (1982). https://doi.org/10.1007/BF01314871

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01314871

Keywords

Search

Navigation