Summary
Phosphonoacetic acid and phosphonoformate were examined as inhibitors ofHerpesvirus sylvilagus replication in cultured cells. Both drugs produced significant inhibition at a minimum concentration of 25 micrograms per milliliter.
This is a preview of subscription content, log in via an institution to check access.
References
Barahona, H., Daniel, M. D., Bekesi, J. G., Fraser, C. E. O., King, N. W., Hunt, R. D., Ingalls, K. J., Jones, T. C.:In vitro suppression ofHerpesvirus saimiri replication by phosphonoacetic acid. Proc. Soc. exp. Biol. Med.154, 431–434 (1977).
Felsenfeld, A. D., Abee, C. R., Gerone, P. J., Soike, K. F., Williams, S. R.: Phosphonoacetic acid in the treatment of simian varicella. Antimicrob. Agents Chemother.14, 331–335 (1978).
Friedman-Kien, A. E., Fondak, A. A., Klein, R. J.: Phosphonoacetic acid treatment of Shope Fibroma and vaccinia virus skin infections in rabbits. J. Invest. Dermatol.66, 99–102 (1976).
Harris, S. R. B., Boyd, B. R.: The activity of iodeoxyuridine, adenine arabinoside, cytosine arabinoside, rabavirin and phosphonoacetic acid against herpesvirus in the hairless mouse model. J. Antimicrob. Chemother.3 (Suppl. A), 91–98 (1977).
Hinze, H.: New member of the herpesvirus group isolated from wild cottontail rabbits. Infect. Immun.3, 350–354 (1971).
Hinze, H.: Induction of lymphoid hyperplasia and lymphoma-like disease in rabbits byHerpesvirus sylvilagus. Int. J. Cancer8, 514–522 (1971).
Huang, E.-S.: Human cytomegalovirus IV. Specific inhibition of virus-induced DNA polymerase activity and viral DNA replication by phosphonoacetic acid. J. Virol.16, 1560–1565 (1975).
Lee, L. F., Nazerian, K., Leinbach, S. S., Reno, J. M., Boezi, J. A.: Effect of phosphonoacetate on Marek's disease virus replication. J. Nat. Cancer Inst.56, 823–827 (1976).
Leinbach, S. S., Reno, J. M., Lee, L. F., Isbell, A. F., Boezi, J. A.: Mechanism of phosphonoacetate inhibition of herpesvirus-induced DNA polymerase. Biochem.15, 426–430 (1976).
Mao, J. C.-H., Robishaw, E. E.: Mode of inhibition of herpes simplex virus DNA polymerase by phosphonoacetate. Biochem.14, 5475–5479 (1975).
May, D. C., Miller, R. L., Rapp, F.: The effect of phosphonoacetic acid on thein vitro replication of varicella-zoster virus. Intervirology8, 83–91 (1977).
Nyormoi, O., Thorley-Lawson, D. A., Elkington, J., Strominger, J. L.: Differential effect of phosphonoacetic acid on the expression of Epstein-Barr viral antigens and virus production. Proc. Nat. Acad. Sci. U.S.A.73, 1745–1748 (1976).
Reno, J. M., Lee, L. F., Boezi, J. A.: Inhibition of herpesvirus replication and herpesvirus-induced deoxyribonucleic acid polymerase by phosphonoacetic acid Antimicrob. Agents Chemother.13, 188–192 (1978).
Roboz, J., Suzuki, R., Hunt, R., Bekesi, G.: Preclinical toxicological study of phosphonoacetic acid: Determination in blood by selected ion monitoring. Biomed. Mass Spectrometry4, 291–296 (1977).
Sabourin, C. L. K., Reno, J. M., Boezi, J. A.: Inhibition of eukaryotic DNA polymerases by phosphonoacetate and phosphonoformate. Arch. Biochem. Biophys.187, 96–101 (1978).
Shipkowitz, N. L., Bower, R. R., Appell, R. N., Nordeen, C. W., Overby, L. R., Roderick, W. R., Schleicher, J. B., von Esch, A. M.: Suppression of herpes simplex virus infection by phosphonoacetic acid. Appl. Microbiol.26, 264–267 (1973).
Summers, W. C., Klein, G.: Inhibition of Epstein-Barr virus DNA synthesis and late gene expression by phosphonoacetic acid. HJ. Virol.18, 151–155 (1976).
Yajima, Y., Tanaka, A., Nonoyama, M.: Inhibition of productive replication of Epstein-Barr virus DNA by phosphonoacetic acid. J. Virol.71, 352–354 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goodrich, J.M., Lee, K.W. & Hinze, H.C. In vitro inhibition ofHerpesvirus sylvilagus by phosphonoacetic acid and phosphonoformate. Archives of Virology 66, 261–264 (1980). https://doi.org/10.1007/BF01314739
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01314739