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Combined interaction of antiherpes substances and interferon β on the multiplication of herpes simplex virus

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Summary

The inhibition of herpes simplex virus type 1 (strain McIntyre) by two antiherpes substances applied in combination was studied by means of a CPE inhibition method in Vero cell microcultures. The following substances were studied: AraA monophosphate, thymine arabinoside, ethyldeoxyuridine, acycloguanosine (acyclovir), 3-fluorothymidine, phosphonoformic acid. Most substance pairs showed a moderate degree of synergism. Two additive interactions and one case of antagonism was observed. Human fibroblast interferon, combined with the antiherpes substances, showed an additive interaction with AraAMP, but synergism with the others.

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  1. Abteilung für Virologie, Institut für Hygiene und Mikrobiologie, Universitätskliniken, Homburg (Saar), Germany

    Christina Janz & R. Wigand

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  1. Christina Janz
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  2. R. Wigand
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Janz, C., Wigand, R. Combined interaction of antiherpes substances and interferon β on the multiplication of herpes simplex virus. Archives of Virology 73, 135–143 (1982). https://doi.org/10.1007/BF01314722

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  • DOI: https://doi.org/10.1007/BF01314722

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