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P53 protein in 204 patients with primary breast carcinoma — immunohistochemical detection and clinical value as a prognostic factor

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Abstract

In a retrospective study, 204 formalin-fixed and paraffin-embedded biopsies of primary breast carcinomas were tested immunohistochemically for the expression of p53 protein (PAb 1801). 38% of the carcinomas were positive with respect to p53. The expression of p53 correlated significantly with the loss of tumor differentiation (P = 0.013), but not with menopausal status, patients' age, tumor size, axillary lymph node involvement or hormone receptor status. The influence of p53 expression on prognosis was evaluated in 197 patients (T1–4 N0–2 M0, median observation time 72 months). Detection of p53 protein was associated with a significantly longer disease-free survival in node-positive women (P = 0.03). However, p53 protein did not prove to be a prognostic factor in node-negative patients. The results demonstrate the prognostic value of p53 expression in breast cancer which appears to be limited to patients with node-positive tumors.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Cologne, D-50924, Köln, Germany

    U-J Göhring, A. Scharl, C. Heckel, A. Ahr & G. Crombach

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  1. U-J Göhring
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  2. A. Scharl
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  3. C. Heckel
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  4. A. Ahr
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  5. G. Crombach
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Correspondence to: U.-J. Gohring

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Göhring, UJ., Scharl, A., Heckel, C. et al. P53 protein in 204 patients with primary breast carcinoma — immunohistochemical detection and clinical value as a prognostic factor. Arch Gynecol Obstet 256, 139–146 (1995). https://doi.org/10.1007/BF01314642

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  • DOI: https://doi.org/10.1007/BF01314642

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