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Use of Brefeldin A to localize block in intracellular transport of vesicular stomatitis virus G protein on interferon-treated cells

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Summary

Brefeldin A (BFA) induced a rapid redistribution of vesicular stomatitis virus G protein (VSV-G) to the endoplasmatic reticulum (ER) in interferon (IFN)-pretreated cells. This result is consistent with accumulation of VSV-G in thetrans-Golgi (GC) complex in cells pretreated with IFN and implies that IFN does not interfere with the ability of BFA to induce redistribution of proteins from GC to ER.

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Authors and Affiliations

  1. Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Czechoslovakia

    K. Polakova

  2. Institute of Virology, Slovak Academy of Sciences, Bratislava, Czechoslovakia

    G. Russ

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  1. K. Polakova
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  2. G. Russ
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Polakova, K., Russ, G. Use of Brefeldin A to localize block in intracellular transport of vesicular stomatitis virus G protein on interferon-treated cells. Archives of Virology 124, 171–179 (1992). https://doi.org/10.1007/BF01314635

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  • DOI: https://doi.org/10.1007/BF01314635

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