Summary
The prolonged administration of rabbit anti-mouse L cell interferon globulin had a marked potentiating effect on Rauscher Murine Leukemia Virus (MuLV-R) infection in BALB/c mice, as shown by spleen size. Normal rabbit globulin had a lesser, but still significant, augmenting effect on splenic enlargement.
It was possible to discriminate quantitatively between the non-specific enhancement of splenomegaly in MuLV-R infected mice due to antigenic stimulation with normal rabbit globulin and the effects due to elimination of endogenous interferon by specific antibodies. The difference in the spleen-enlarging activity between the anti-interferon IgG and normal rabbit IgG was found to be maximal 3–4 weeks after infection when potent, diluted anti-interferon IgG (58 µg protein per dose) was used.
It would appear that the endogenous interferon, even produced in undetectable amounts, plays an essential role in controlling infection with an oncogenic virus.
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Cerny, J., Essex, M., Thomas, D. B.: Interactions of murine leukemia virus (MuLV) with isolated lymphocytes. III. Alterations of splenic B and T cells in Friend virus-infected mice. Intern. J. Cancer18, 197–204 (1976).
Fauconnier, B.: Augmentation de la pathogénicité virale par l'emploi de sérum anti-interferonin vivo. Comp. Rend. Acad. Sci.271, 1464–1466 (1970).
Fenner, F.: The classification and nomenclature of viruses. Summary of results of meetings of the International Committee on Taxonomy of Viruses in Madrid, September 1975. Intervirology6, 1–12 (1975/76).
Furmanski, P., Juni, S., Hall, L., Rich, M. A.: The role of interferon in the spontaneous regression of Friend virus induced leukemia. Proc. Soc. exp. Biol. Med.150, 11–14 (1975).
Gresser, I.: Antitumor effects of interferon. Adv. Cancer Res.16, 97–140 (1972).
Gresser, I., Berman, L., Thé, G. de, Brouty-Boyè, D., Coppey, J., Falcoff, E.: Interferon and murine leukemia. V. Effect of interferon preparations on the evolution of Rauscher disease in mice. J. Natl. Cancer Inst.41, 505–522 (1968).
Gresser, I., Maury, C., Tovey, M. G.: Interferon and murine leukemia. VII. Therapeutic effect of interferon preparations after diagnosis of lymphoma in AKR mice. Intern. J. Cancer17, 647–651 (1976).
Gresser, I., Tovey, M. G., Bandu, M. T., Maury, C., Brouty-Boyè, D.: Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection. J. exp. Med.144, 1305–1315 (1976).
Gresser, I., Tovey, M. G., Maury, C., Bandu, M. T.: Role of interferon in the pathogenesis of virus deseases in mice as demonstrated by the use of anti-interferon serum. II. Studies with Herpes Simplex, Moloney Sarcoma, Vesicular Stomatitis, Newcastle Disease and Influenza Viruses. J. exp. Med.144, 1316–1323 (1976).
Hanna, M. G., Jr., Walburg, H. E., Jr., Tyndall, R. L., Snodgrass, M. J.: Histoproliferative effect of Rauscher Leukemia Virus on lymphatic tissue. II. Antigen stimulated germfree and conventional BALB/c mice. Proc. Soc. exp. Biol. Med.134, 1132–1141 (1970).
Hirsch, M. S., Murphy, F. A.: Effects of anti-thymocyte serum on Rauscher virus infection in mice. Nature218, 478–479 (1968).
Inglot, A. D., Albin, M., Chudzio, T.: Persistent infection of mouse cells with Sindbis virus: role of virulence of strains, auto-interfering particles and interferon. J. gen. Virol.20, 105–110 (1973).
Inglot, A. D., Chudzio, T.: A bioassay employing polyethylene glycol for measuring neutralization of interferon by specific antibodies. J. immunol. Meth.13, 63–69 (1976).
Jerne, N. D., Nordin, A. A., Henry, C.: The agar plaque technique for recognizing antibody—producing cells. In:Amos, B., Koprowski, H. (eds.), Cell Bound Antibodies, 109–130. Philadelphia: Wistar Institute Press 1963.
Kisielow, B., Inglot, A. D., Chudzio, T.: Biological activity of sera from rabbits hyperimmunized with the mouse L cell interferon. Arch. Immun. Therap. Exp. 1977 (in press).
Kouttab, N. M., Jutila, J. W.: Friend leukemia virus infection in germfree mice following antigen stimulation. J. Immunol.108, 591–595 (1972).
Larson, C. L., Ushijimi, R. N., Baker, R. E., Baker, M. B., Gillespie, C. A.: Effect of normal serum and anti-thymocyte serum on Friend disease in mice. J. Natl. Cancer Inst.48, 1403–1407 (1972).
Nooter, K., Bentveltzen, P.:In vitro studies on the enhancement of Rauscher virus induced erythroblastosis by complete Freund's adjuvant in BALB/c mice. J. Natl. Cancer Inst.57, 115–118 (1976).
Siegel, B. V., Morton, J. I.: Immunologic stimuli in relation to leukemogenesis. I. Potentiation of Rauscher viral leukemia by Freund's adjuvant. J. Natl. Cancer Inst.48, 1681–1686 (1972).
Siegel, B. V., Brown, McK., Morton, J. I.: Interferon induction in New Zealand Black mice by Murine Leukemia Virus. J. Immunol.111, 644–646 (1973).
Toth, F. D., Vàczi, L., Balogh, M.: The role of tumor specific antibody and interferon production in the pathogenesis of Rauscher leukemia. Acta virol.18, 57–64 (1974).
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Grant from Polish Academy of Sciences 10.5.
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Inglot, A.D., Chudzio, T. Enhancement of leukemogenesis in mice after prolonged administration of anti-interferon or normal rabbit globulin. Archives of Virology 55, 67–75 (1977). https://doi.org/10.1007/BF01314480
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DOI: https://doi.org/10.1007/BF01314480