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Rat lymphoid cell lines with HTLV-I production

III. Transmission of HTLV-I into rats and analysis of cell surface antigens associated with HTLV-I

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Summary

Newborn WKA rats given a single intraperitoneal injection of MMC treated TARS-1, a rat T cell line producing HTLV-I, were shown to accumulate high titred antibodies specific for HTLV-I. Adult WKA rats rejected TARS-1 transplant with transient appearance of anti-HTLV-I antibodies. However, rats maintained under daily administration of Bredinin, an immunosuppressive drug after TARS-1 transplant showed continuous production of antibodies specific for HTLV-I by aging. Type-C virus particles similar to HTLV-I were demonstrated by electronmicroscopy in the short-term cultured spleen cells of these rats. The evidence indicates that HTLV-I can be transmitted into newborn and immunosuppressed adult rats and they may provide a suitable animal model of ATL and related conditions in man, especially for elucidating the virus-host interactions involved in the leukemogenesis of HTLV-I. By using monoclonal antibodies, cell surface antigens associated with HTLV-I were also analysed.

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Authors and Affiliations

  1. Department of Pathology, Sapporo City General Hospital, Sapporo, Japan

    T. Yoshiki, N. Kondo, M. Tateno & T. Itoh

  2. Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan

    T. Chubachi & T. Togashi

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  1. T. Yoshiki
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  2. N. Kondo
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  3. T. Chubachi
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  4. M. Tateno
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  5. T. Togashi
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  6. T. Itoh
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Yoshiki, T., Kondo, N., Chubachi, T. et al. Rat lymphoid cell lines with HTLV-I production. Archives of Virology 97, 181–196 (1987). https://doi.org/10.1007/BF01314420

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  • DOI: https://doi.org/10.1007/BF01314420

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