Summary
Immunogold electron microscopy revealed that site-specific antibodies elicited by a synthetic peptide representing the N-terminal sequence (residues 2–10) of influenza virus M 2 protein were capable of binding to the surface of virions. Antibody binding was observed with two human influenza virus strains but not with an avian virus strain which has amino acid substitutions in the appropriate sequence of M 2. These results provide direct evidence for the presence of M 2 in the influenza virion.
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Jackson, D.C., Tang, XL., Murti, K.G. et al. Electron microscopic evidence for the association of M 2 protein with the influenza virion. Archives of Virology 118, 199–207 (1991). https://doi.org/10.1007/BF01314030
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DOI: https://doi.org/10.1007/BF01314030