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Borna disease, a possible hazard for man?

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Summary

Evidence is presented that Borna disease (BD) virus, which is known to cause encephalopathy in horses, sheep, and a broad range of experimental animals, or a related agent, can infect man and may induce mental disorders. BD virus-specific antibodies could be demonstrated in 4–7% of sera (depending on origin) from more than 5000 psychiatric or neurological patients from Germany, U.S.A. and Japan. Antibodies from seropositive patients reacted with a BD virus-specific protein translated by RNAs which were transcribed from a cDNA clone obtained from BD virus-infected tissues. When the cerebrospinal fluid from three seropositive patients was inoculated into rabbits or rabbit embryonic brain cell cultures, evidence was obtained that suggests the presence of BD virus or a related agent.

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References

  1. Amsterdam JD, Winokur H, Dyson W, Herzog S, Rott R, Koprowski H (1985) Borna disease virus: a possible etiologic factor in human affective disorders? Arch Gen Psychiatry 42: 1093–1096

    Google Scholar 

  2. Bechter K, Herzog S, Fleischer B, Schüttler R, Rott R (1987) Kernspintomographische Befunde bei psychiatrischen Patienten mit und ohne Serum-Antikörper gegen das Virus der Bornaschen Krankheit. Nervenarzt 58: 617–624

    Google Scholar 

  3. Carbone KM, Duchala CS, Griffin JW, Kincaid AC, Narayan O (1987) Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation. J Virol 61: 3431–3440

    Google Scholar 

  4. Deschl U, Stitz L, Herzog S, Frese K, Rott R (1990) Determination of immune cells and expression of major histocompatibility complex class II antigen in encephalitic lesions of experimental Borna disease. Acta Neuropathol 81: 41–50

    Google Scholar 

  5. Duchala CS, Carbone KM, Narayan O (1989) Preliminary studies on biology of Borna disease virus. J Gen Virol 70: 3507–3511

    Google Scholar 

  6. Gosztonyi G, Ludwig H (1984) Borna disease of horses. An immunohistological and virological study of naturally infected animals. Acta Neuropathol 64: 213–221

    Google Scholar 

  7. Haas B, Becht H, Rott R (1986) Purification and properties of an intranuclear virus-specific antigen from tissue infected with Borna disease virus. J Gen Virol 67: 235–241

    Google Scholar 

  8. Heinig A (1969) Die Bornasche Krankheit der Pferde und Schafe. In: Röhrer H (ed) Handbuch der Virusinfektionen bei Tieren, vol 4. G Fischer, Jena, pp 83–148

    Google Scholar 

  9. Herzog S, Rott R (1980) Replication of Borna disease virus in cell cultures. Med Microbiol Immunol 168: 153–158

    Google Scholar 

  10. Herzog S, Kompter C, Frese K, Rott R (1984) Replication of Borna disease virus in rats: age dependent differences in tissue distribution. Med Microbiol Immunol 173: 171–177

    Google Scholar 

  11. Herzog S, Wonigeit K, Frese K, Hedrich HJ, Rott R (1985) Effect of Borna disease virus infection in athymic rats. J Gen Virol 66: 503–508

    Google Scholar 

  12. Hirano N, Kao M, Ludwig H (1983) Persistent tolerant or subacute infections in Borna disease virus-infected rats. J Gen Virol 64: 1521–1530

    Google Scholar 

  13. Krey H, Ludwig H, Rott R (1979) Spread of infectious virus along the optic nerve into the retina in Borna disease virus-infected rabbits. Arch Virol 61: 283–288

    Google Scholar 

  14. Lange H, Herzog S, Herbst W, Schliesser T (1987) Seroepidemiologische Untersuchungen zur Bornaschen Krankheit der Pferde. Tierärztl Umschau 42: 938–946

    Google Scholar 

  15. Lipkin WJ, Travis GH, Carbone KM, Wilson MC (1990) Isolation and characterization of Borna disease agent cDNA clones. Proc Natl Acad Sci USA 87: 4184–4188

    Google Scholar 

  16. Ludwig H, Koester V, Pauli G, Rott R (1977) The cerebrospinal fluid of rabbits infected with Borna disease virus. Arch Virol 55: 209–223

    Google Scholar 

  17. Ludwig H, Bode L, Gosztonyi G (1988) Borna disease: a persistent virus infection of the central nervous system. Progr Med Virol 35: 107–151

    Google Scholar 

  18. Morales JH, Herzog S, Kompter C, Frese K, Rott R (1988) Axonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats. Med Microbiol Immunol 177: 51–68

    Google Scholar 

  19. Narayan O, Herzog S, Frese K, Scheefers H, Rott R (1983) Behavioral disease in rats caused by immunopathological responses to persistent Borna virus in the brain. Science 220: 1401–1403

    Google Scholar 

  20. Narayan O, Herzog S, Frese K, Scheefers H, Rott R (1983) Pathogenesis of Borna disease in rats: immune mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities. J Infect Dis 148: 305–315

    Google Scholar 

  21. Nicolau S, Galloway IA (1928) Borna disease and enzootic encephalitis of sheep and cattle. Spec Rep Ser Med Res Council 121: 7–90

    Google Scholar 

  22. Richt JA, Stitz L, Wekerle H, Rott R (1989) Borna disease, a progressive meningoencephalomyelitis as a model of CD4+ T cell-mediated immunopathology in the brain. J Exp Med 170: 1045–1050

    Google Scholar 

  23. Richt J, Stitz L, Deschl U, Frese K, Rott R (1990) Borna disease virus-induced meningoencephalomyelitis caused by a virus-specific CD4+ T cell-mediated immune reaction. J Gen Virol 71: 2565–2573

    Google Scholar 

  24. Rott R, Herzog S, Fleischer B, Winokur H, Amsterdam J, Dyson W, Koprowski H (1985) Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science 228: 755–756

    Google Scholar 

  25. Sprankel H, Richarz K, Ludwig H, Rott R (1979) Behavior alterations in tree shrew (Tupaia glis, Diard) induced by Borna disease virus. Med Microbiol Immunol 165: 1–18

    Google Scholar 

  26. Stitz L, Schilken D, Frese K (1991) Atypical dissemination of the highly neurotropic Borna disease virus during persistent infection in Cyclosporin A-treated immunosuppressed rats. J Virol 65: 457–460

    Google Scholar 

  27. Stitz L, Soeder S, Deschl U, Frese K, Rott R (1989) Inhibition of immune-mediated meningoencephalitis in persistently Borna disease virus-infected rats by Cyclosporin A. J Immunol 143: 4250–4256

    Google Scholar 

  28. VandeWoud S, Richt JA, Zink MC, Rott R, Narayan O, Clements JE (1990) A Borna disease virus cDNA clone encoding a protein recognized by antibodies in humans with behavioral diseases. Science 250: 1278–1281

    Google Scholar 

  29. Zwick W (1939) Bornasche Krankheit und Encephalomyelitis der Tiere. In: Gildemeister F, Hagen E, Waldmann O (eds) Handbuch der Viruskrankheiten, vol 2. G Fischer, Jena, 254–354

    Google Scholar 

  30. Zwick W, Witte J, Bert F (1932) Über das Vorkommen des Virus der Bornaschen Krankheit im Harn, im Blut und im Liquor cerebrospinalis. Berl Tierärztl Wochenschr 48: 336–337

    Google Scholar 

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Authors and Affiliations

  1. Institute für Virologie, Justus-Liebig-Universität Giessen, Giessen, Germany

    R. Rott & S. Herzog

  2. Institute für Veterinär-Pathologie, Justus-Liebig-Universität Giessen, Giessen, Germany

    K. Frese

  3. Bezirkskrankenhaus Günzburg, Günzburg, Germany

    K. Bechter

Authors
  1. R. Rott
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  2. S. Herzog
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  3. K. Bechter
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  4. K. Frese
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Rott, R., Herzog, S., Bechter, K. et al. Borna disease, a possible hazard for man?. Archives of Virology 118, 143–149 (1991). https://doi.org/10.1007/BF01314025

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  • DOI: https://doi.org/10.1007/BF01314025

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