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Three new cases of R-type virus-like particles in hamster tumours

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Summary

R-type virus-like particles (VLP) in fibrosarcoma and myeloid tumour induced in hamsters with the myeloleukaemic virus of Graffi and in hamster embryonic fibroblasts infected with the lympholeukaemic virus Ly/Ya are described. The particles are found in the cysternae of the rough surface endoplasmic reticulum (RER). The VLP are classified as endogenous virus (EV) whose expression is determined by the initial infection with murine leukaemia virus (MLV).

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References

  1. Bergmann DG, Wolff DA (1981) Production of R-type virus-like particles in hamster cells. Intervirology 16: 61–70

    Google Scholar 

  2. Bernhard W, Tournier P (1964) Infection virale inapparente de cellules de hamsters decelee par la microscopie electronique. Ann Inst Pasteur 107: 447–452

    Google Scholar 

  3. Cesarini JP, de Micco C (1972) Studies on type-H virus-like particles in hamster: their role in oncogenesis. Int J Cancer 10: 174–185

    Google Scholar 

  4. Coffin J (1982) Endogenous viruses. In: Weiss R, Teich N, Varmus H, Coffin J (eds) RNA tumour viruses. Cold Spring Harbor Laboratory, Cold Spring Harbor, pp 1109–1205

    Google Scholar 

  5. Courtney MG, Schmidt LJ, Getz MJ (1982) Organization and expression of endogenous virus-like (VL-30) DNA sequence in non-transformed and chemically transformed mouse embryo cells in cultures. Cancer Res 42: 569–576

    Google Scholar 

  6. De Harven E (1974) Remarks on the ultrastructure of type A, B, and C virus particles. Adv Virus Res 19: 221–264

    Google Scholar 

  7. Graham DE, Medina D, Smith GH (1984) Increased concentration of an endogenous proviral mouse mammary tumour virus long terminal repeat-containing transcript is associated with neoplastic transformation of mammary epithelium in C3H/Sm mice. J Virol 49: 819–827

    Google Scholar 

  8. Kirschmeier P, Gattoni-Celli S, Dina D, Weinstein IB (1982) Carcinogen- and radiation-transformed C3H 10T1/2 cells contain RNAs homologous to the long terminal repeat sequence of a murine leukemia virus. Proc Natl Acad Sci USA 79: 2773–2777

    Google Scholar 

  9. Lasneret J, Lesser J, Dianoux L, Canivet M, Bittoun P, Peries J (1989) Electron microscopic characterisation of retrovirus and retrovirus-like particles induced by demethylating agents (5-azacytidine and 5-azadeoxycytidine) in Syrian hamster (Mesocricetus Auratus) cells. J Exp Pathol 4: 47–55

    Google Scholar 

  10. Roussev R, Mladenov Z, Yakimov M, Toshkov I (1983) Transplantable fibrosarcoma in hamster—pathomorphologic characteristics. Gen Comp Pathol 13: 8–13

    Google Scholar 

  11. Royston ME, Augenlicht LH (1983) Biotinated probe containing a long terminal repeat hybridized to a mouse colon tumour and normal tissue. Science 222: 1339–1341

    Google Scholar 

  12. Shipman CJ, Van der Weide GC, Il Ma B (1969) Prevalence of type R virus-like particles in clones of BHK 21 cells. Virology 38: 707–710

    Google Scholar 

  13. Thomas JA (1964) Relations ultrastructurales d'un virus et du chondriome: comparaison de l'evolution virale dans les cellules BHK 21/13, dans les cellules cancereuse induites par celles-ci et dans les cellules H 54. CR Acad Sci Paris Ser D 258: 6018–6021

    Google Scholar 

  14. Yakimov M, Mladenov Z, Konstantiniov A, Yantchev I (1979) Transplantable myeloid tumour in hamsters induced by the Graffi virus. Gen Comp Pathol 6: 24–35

    Google Scholar 

  15. Yakimov M, Argirova R, Dimitrov T, Polyanova M (1987) Antigenic determination of the type of a local murine lympholeukosis virus strain. Gen Comp Pathol 22: 60–66

    Google Scholar 

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Roussev, R., Polianova, M. & Toshkova, R. Three new cases of R-type virus-like particles in hamster tumours. Archives of Virology 133, 485–489 (1993). https://doi.org/10.1007/BF01313786

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  • DOI: https://doi.org/10.1007/BF01313786

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