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Consumption coagulopathy associated with shock in acute African swine fever

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Summary

We studied the evolution of shock using a comprehensive array of haematological tests in pigs infected with the highly virulent strain Malawi '83 (Lilongwe 20/1). A sudden onset of illness was observed between day 5 and 7 after inoculation with development of flush, episodes of epistaxis and melaena. Prior to these clinical signs, initiation of a consumption coagulopathy was demonstrated with loss of antithrombin III and plasminogen activity. Our findings indicate that during infection with this highly virulent strain the development of a consumption coagulopathy precedes and possibly contributes to shock, which results in haemorrhage and death.

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Authors and Affiliations

  1. Centro de Biología Molecular (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain

    C. J. Villeda & E. Viñuela

  2. Pirbright Laboratory, A.F.R.C., Institute for Animal Health, Pirbright, Surrey, U.K.

    S. M. Williams & P. J. Wilkinson

Authors
  1. C. J. Villeda
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  2. S. M. Williams
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  3. P. J. Wilkinson
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  4. E. Viñuela
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Villeda, C.J., Williams, S.M., Wilkinson, P.J. et al. Consumption coagulopathy associated with shock in acute African swine fever. Archives of Virology 133, 467–475 (1993). https://doi.org/10.1007/BF01313784

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  • DOI: https://doi.org/10.1007/BF01313784

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