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Molecular cloning of the Rauscher murine leukemia virus

Disease spectrum and integration pattern

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Summary

After transfection of NIH 3T3 cells with DNA from molecularly cloned Rauscher MuLV, virus was isolated which showed a disease spectrum comparable to that of R-MuLV cloned biologically by endpoint dilution. In both cases sites of proviral integration vary from 2–5 per leukemic tissue and occur apparently at random.

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Authors and Affiliations

  1. Department of Pathology, Faculty of Medicine, Erasmus University Rotterdam, Rotterdam, The Netherlands

    M. J. M. van der Feltz, M. E. Kranendonk-Odijk, E. H. Rhijnsburger, J. Stark, K. Stoker & N. J. de Both

Authors
  1. M. J. M. van der Feltz
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  2. M. E. Kranendonk-Odijk
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  3. E. H. Rhijnsburger
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  4. J. Stark
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  5. K. Stoker
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  6. N. J. de Both
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van der Feltz, M.J.M., Kranendonk-Odijk, M.E., Rhijnsburger, E.H. et al. Molecular cloning of the Rauscher murine leukemia virus. Archives of Virology 108, 115–120 (1989). https://doi.org/10.1007/BF01313748

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  • DOI: https://doi.org/10.1007/BF01313748

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