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Evidence for an inherited predisposition to alcoholic pancreatitis

A controlled HLA typing study

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Abstract

To investigate the role of heredity in alcoholic pancreatitis, an HLA typing study has been performed. Patients with alcoholic pancreatitis exhibited an increased frequency of HLA Bw 39 when compared with the general population [13.6% vs 3.3%, P (corrected) <0.02; relative risk 4.7]. Alcoholics without pancreatitis did not differ from the general population with respect to HLA status, indicating that the increased incidence of HLA Bw 39 was related to alcoholic pancreatitis rather than to alcoholism itself. Thus, this study has provided evidence for a genetic predisposition to alcoholic pancreatitis.

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Authors and Affiliations

  1. Department of Gastroenterology, Division of Medicine, Prince Henry Hospital, Little Bay, 2036, Sydney, N.S.W., Australia

    J. S. Wilson MB, BS, D. Gossat MB, BS, A. Tait MB, BS, S. Rouse BSc, Xu Jeng Juan MD &  R. C. Pirola MD

  2. The Red Cross Blood Transfusion Service, Sydney, N.S.W., Australia

    J. S. Wilson MB, BS, D. Gossat MB, BS, A. Tait MB, BS, S. Rouse BSc, Xu Jeng Juan MD &  R. C. Pirola MD

Authors
  1. J. S. Wilson MB, BS
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  2. D. Gossat MB, BS
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  3. A. Tait MB, BS
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  4. S. Rouse BSc
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  5. Xu Jeng Juan MD
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  6. R. C. Pirola MD
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Additional information

The work was supported in part by the National Health and Medical Research Council of Australia, The Australian Associated Brewers, and the Clive and Vera Ramaciotti Foundations.

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Wilson, J.S., Gossat, D., Tait, A. et al. Evidence for an inherited predisposition to alcoholic pancreatitis. Digest Dis Sci 29, 727–730 (1984). https://doi.org/10.1007/BF01312945

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  • DOI: https://doi.org/10.1007/BF01312945

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