Numerical deconvolution by least squares: Use of polynomials to represent the input function
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A new method for numerical deconvolution is described, for use in calculating drug input rates. The method is based on the least-squares criterion and approximates the input rate by a polynomial function. Ill-conditioning of the normal equations is avoided by using orthogonal functions. The use of the method is illustrated by means of examples, using simulated data.
Key wordsnumerical deconvolution linear systems analysis calculation of drug input rates calculation ofin vivo dissolution rates polynomials orthogonal functions leasts-quares fitting
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