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Novel method of estimating volume of distribution of a drug obeying Michaelis-Menten elimination kinetics

  • Yi-Jong Lin
  • Donald J. Weidler
  • Dyal C. Garg
  • John G. Wagner
Article

Abstract

The novel method of estimating the volume of distribution involves (a) administering an appropriate bolus intravenous dose of the drug, (b) starting a constant-rate intravenous infusion of the drug at the same time, (c) maintaining the infusion for a given number of hours, (a) measuring the drug concentration over the entire time course, (e) computer-fitting the post-infusion data to obtain estimates of Vm and Km, (f) estimating the total area under the concentration-time curve from zero time to infinity, and (g) iteratively solving a cubic equation to obtain the estimate of the volume of distribution. The method was applied to ethanol in the cat and yielded an average value of 635ml/kg (63.5% of body weight) with a coefficient of variation of 23.0%. This is equivalent to total body water in the cat.

Key words

ethanol volume of distribution Michaelis-Menten elimination kinetics 

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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • Yi-Jong Lin
    • 1
  • Donald J. Weidler
    • 2
  • Dyal C. Garg
    • 1
  • John G. Wagner
    • 1
  1. 1.College of PharmacyThe University of MichiganAnn Arbor
  2. 2.Department of Internal Medicine, School of MedicineThe University of MichiganAnn Arbor

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