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Detection of measles virus genome in blood leucocytes of patients with certain autoimmune diseases

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Summary

RNA isolated from lymphocytes of peripheral blood was dot-hybridized to a hybrid plasmid containing specific sequences for measles virus nucleocapsid protein. Viral RNA was detected in the lymphocytes of 28 of 34 (82%) patients with systemic lupus erythematosus (SLE) and of 40 of 68 (59%) patients with chronic glomerulonephritis (CGN), and was not detected in 29 control patients.

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Authors and Affiliations

  1. Laboratory of Chronic Viral Infections, Moscow Research Institute for Viral Preparations, Academy of Medical Sciences U.S.S.R., Moscow, USSR

    O. G. Andjaparidze, N. M. Chaplygina, N. N. Bogomolova, I. B. Koptyaeva, E. G. Nevryaeva, R. G. Filimonova & I. E. Tareeva

  2. Problem Nephrology Laboratory, 1st Sechenov Medical Institute, Moscow, USSR

    O. G. Andjaparidze, N. M. Chaplygina, N. N. Bogomolova, I. B. Koptyaeva, E. G. Nevryaeva, R. G. Filimonova & I. E. Tareeva

Authors
  1. O. G. Andjaparidze
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  2. N. M. Chaplygina
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  3. N. N. Bogomolova
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  4. I. B. Koptyaeva
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  5. E. G. Nevryaeva
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  6. R. G. Filimonova
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  7. I. E. Tareeva
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Andjaparidze, O.G., Chaplygina, N.M., Bogomolova, N.N. et al. Detection of measles virus genome in blood leucocytes of patients with certain autoimmune diseases. Archives of Virology 105, 287–291 (1989). https://doi.org/10.1007/BF01311364

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  • DOI: https://doi.org/10.1007/BF01311364

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