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Characterization of a new polyomavirus (Polyomavirus papionis-2) isolated from baboon kidney cell cultures

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Summary

Viruses with papovavirus morphology were seen in fluids from baboon kidney cell cultures on three separate occasions (isolates A, B, and C). The size of the virions, 47.9 nm, placed the virus in the polyomavirus genus. It grew well in baboon kidney and Vero cells and less well in human embryo lung (HEL) fibroblasts.

The virus could not be identified as the previously described baboon polyomavirus, SA 12, or as any of the other known primate polyomaviruses BK, JC or SV 40, the non-primate viruses mouse polyoma, K, rabbit kidney vacuolating virus (RKV) or bovine polyomavirus (FRKV) by immunofluorescence, immune electron microscopy or hemagglutination inhibition (HI) tests. A rabbit antiserum to the new virus (isolate A) reacted only with the three isolates and not with the other primate polyomaviruses studied.

Thirteen percent of 118 wild-caught baboons (Papio anubis) had HI antibody to the new polyomavirus and 21 percent were seropositive for SA 12; only two baboons had antibody to both viruses. These results suggest that in baboons there are two antigenically distinct polyomaviruses which circulate independently. The two viruses may also be distinguished by their hemagglutinating properties: SA 12 agglutinated erythrocytes from a wider range of species but only the newly recognized polyomavirus agglutinated baboon erythrocytes.

We propose that the two baboon viruses, SA 12 and the new virus, should be namedPolyomavirus papionis-1 andPolyomavirus papionis-2 respectively.

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References

  1. Braun L, Kalter SS, Yakovleva LA, Kaschula VR, Shah KV (1980) Neutralizing antibodies to simian papovavirus SA 12 in old world primates in laboratory colonies: high prevalence in baboons. J Med Primatol 9: 240–246

    Google Scholar 

  2. Coackley W, Maker D, Smith VW (1980) A possible bovine polyomavirus. Arch Virol 66: 161–166

    Google Scholar 

  3. Gardner SD (1973) Prevalence in England of antibody to human polyomavirus (B.K.). Br Med J 1: 77–78

    Google Scholar 

  4. Hartley JW, Rowe WP (1964) New papovavirus contaminating Shope papillomata. Science 143: 258–260

    Google Scholar 

  5. Huebner RJ, Rowe WP, Hartley JW, Lane WT (1962) Mouse polyoma virus in rural ecology. In: Wolstenholme GEW, O'Connor M (eds) Tumour viruses of murine origin. Ciba Foundation Symposium, 1961. Churchill, London, pp 314–328

    Google Scholar 

  6. Lecatsas G, Malherbe HH, Strickland-Cholmley M (1977) Electronmicroscopical characterization of simian papovavirus SA 12. J Med Microbiol 10: 477–478

    Google Scholar 

  7. Malherbe H, Harwin R, Ulrich M (1963) The cytopathic effects of vervet monkey viruses. S Afr Med J 37: 407–411

    Google Scholar 

  8. Matthews REF (1982) Classification and nomenclature of viruses. Fourth Report of the International Committee on Taxonomy of Viruses. Intervirology 17: 62–63

    Google Scholar 

  9. Matthews REF (1982) Classification and nomenclature of viruses. Intervirology 17: 23–25

    Google Scholar 

  10. Padgett BL, Walker DL (1973) Prevalence of antibodies in human sera against JC virus, an isolate from a case of progressive multifocal leukoencephalopathy. J Infect Dis 127: 467–470

    Google Scholar 

  11. Parry JV, Lucas MH, Richmond JE, Gardner SD (1983) Evidence for a bovine origin of the polyomavirus detected in foetal rhesus monkey kidney cells, FRhK-4 and -6. Arch Virol 78: 151–165

    Google Scholar 

  12. Richmond JE, Parry JV, Gardner SD (1984) Characterization of a polyomavirus in two foetal rhesus monkey kidney cell lines used for the growth of hepatitis A virus. Arch Virol 80: 131–146

    Google Scholar 

  13. Rowe WP, Hartley JW, Huebner RJ (1963) Polyoma and other indigenous mouse viruses. Lab Anim Care 13 [Suppl]: 166–175

    Google Scholar 

  14. Shah KV, Valis JD, Daniel RW (1978) Hemagglutination with simian papovavirus SA 12. J Clin Microbiol 7: 396–398

    Google Scholar 

  15. Sweet BH, Hilleman MR (1960) The vacuolating virus, S.V. 40. Proc Soc Exp Biol Med 105: 420–427

    Google Scholar 

  16. Takemoto KK, Furuno A, Kato K, Yoshiike K (1982) Biological and biochemical studies of African green monkey lymphotropic papovavirus. J Virol 42: 502–509

    Google Scholar 

  17. Valis JD, Newell N, Reissig M, Malherbe H, Kaschula VR, Shah KV (1977) Characterization of SA 12 as a simian virus 40-related papovavirus of chacma baboons. Infect Immun 18: 247–252

    Google Scholar 

  18. Wognum AW, Sol CJA, van der Noordaa J, van Steenis G, Osterhaus ADME (1984) Isolation and characterization of a papovavirus from Cynomolgus Macaque kidney cells. Virology 134: 254–257

    Google Scholar 

  19. Zur Hausen H, Gissmann L (1979) Lymphotropic papovaviruses isolated from African green monkey and human cells. Med Microbiol Immunol 167: 137–153

    Google Scholar 

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Authors and Affiliations

  1. Virus Reference Laboratory, Central Public Health Laboratory, Colindale, London, England

    Sylvia D. Gardner, Wendy A. Knowles, J. F. Hand & A. A. Porter

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  1. Sylvia D. Gardner
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  2. Wendy A. Knowles
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  3. J. F. Hand
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  4. A. A. Porter
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Gardner, S.D., Knowles, W.A., Hand, J.F. et al. Characterization of a new polyomavirus (Polyomavirus papionis-2) isolated from baboon kidney cell cultures. Archives of Virology 105, 223–233 (1989). https://doi.org/10.1007/BF01311359

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  • DOI: https://doi.org/10.1007/BF01311359

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