Summary
Rat virus (RV) was detected by explant culture for up to 14 weeks in rats inoculated as infants and for up to 7 weeks in rats inoculated as juveniles, although both groups were seropositve by 3 weeks post-inoculation.
References
Bergs VV (1969) Rat virus-mediated suppression of leukemia induction by Maloney virus in rats. Cancer Res 28: 1669–1672
Campbell DA, Staal SP, Manders EK, Bonnard GD, Oldham RK, Salzman LA, Herberman RB (1977) Inhibition of in vitro lymphoproliferative responses by in vivo passaged rat 13762 mammary adenocarcinoma cells. II. Evidence that Kilham rat virus is responsible for the inhibitory effect. Cell Immunol 38: 278–391
Jacoby RO, Bhatt PN, Gaertner DJ et al (1987) The pathogenesis of rat virus infection in infant and juvenile rats after oronasal inoculation. Arch Virol 95 (in press)
Jacoby RO, Gaertner DJ, Bhatt PN, Paturzo FX, Smith AL (1987) Transmission of experimentally induced rat virus infection. Lab Anim Sci (in press)
Kilham L (1966) Viruses of laboratory and wild rats. Natl Cancer Inst Monogr 20: 117–135
Kilham L, Olivier L (1959) A latent virus of rats isolated in tissue culture. Virology 7: 428–437
Lipton H, Nathanson N, Hodous J (1972) Enteric transmission of parvoviruses: pathogenesis of rat virus infection in adult rats. Am J Epidemiol 96: 443–446
Margolis G, Kilham L (1965) Rat virus, an agent with an affinity for the dividing cell. In: Gadjusek DC, Gibbs CJ, Alpers M (eds) Slow, latent and temperate virus infections. NINDB Monogr 2. U.S. Department of Health, Educational Welfare, pp 361–367
Nottay BK, Kew OM, Hatch MH, Heyward JT, Obijeski JF (1981) Molecular variation of type 1 vaccine-related and wild polioviruses during replication in humans. Virology 108: 405–423
Parrish CR, O'Connell PH, Evermann JF, Carmichael LE (1985) Natural variation of canine parvoviruses. Science 230: 1046–1048
Robey RE, Woodman DR, Hetrick FM (1968) Studies on the natural infection of rats with the Kilham rat virus. Am J Epidemiol 88: 139–143
Smith AL (1983) Response of weanling random-bred mice to inoculation with minute virus of mice. Lab Anim Sci 83: 37–39
Stevens JG, Cook ML (1971) Latent herpes simplex virus in spiral ganglia of mice. Science 173: 843
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Paturzo, F.X., Jacoby, R.O., Bhatt, P.N. et al. Persistence of rat virus in seropositive rats as detected by explant culture. Archives of Virology 95, 137–142 (1987). https://doi.org/10.1007/BF01311341
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DOI: https://doi.org/10.1007/BF01311341