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Effects of dietary butter fat on fecal bile acid excretion in patients with Crohn's disease on elemental diet

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Abstract

The excretion rate of fecal bile acids was determined by gas-liquid chromatography in nine patients with Crohn's disease and six healthy volunteers under two dietary conditions with different amounts of fat: during nasoduodenal tube feeding with a fat-restricted elemental diet containing approximately 1.5 g/day of fat, and during the addition of 50 g/day of butterfat by peroral administration. The fecal bile acid excretion rate on the elemental diet was significantly greater in the patients with Crohn's disease than in the healthy controls. With ingestion of the additional fat, the excretion rate was significantly increased in the patients with Crohn's disease, but not significantly changed in the healthy controls. The bile acid excretion rate in Crohn's disease correlated with fecal fat excretion, but not with either fecal weight or disease activity. These studies show that the amount of dietary fat represents an important consideration in the evaluation of bile acid malabsorption in Crohn's disease.

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Authors and Affiliations

  1. First Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka City, Japan

    Toichiro Koga MD,  Tatsuro Nishida MD, Hiroshi Miwa BS, Magobei Yamamoto PhD, Kazuma Kaku MD, Tsuneyoshi Yao MD & Makoto Okumura MD

  2. the Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka City, Japan

    Toichiro Koga MD,  Tatsuro Nishida MD, Hiroshi Miwa BS, Magobei Yamamoto PhD, Kazuma Kaku MD, Tsuneyoshi Yao MD & Makoto Okumura MD

  3. Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, 812, Fukuoka City, Japan

    Toichiro Koga MD,  Tatsuro Nishida MD, Hiroshi Miwa BS, Magobei Yamamoto PhD, Kazuma Kaku MD, Tsuneyoshi Yao MD & Makoto Okumura MD

Authors
  1. Toichiro Koga MD
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  2. Tatsuro Nishida MD
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  3. Hiroshi Miwa BS
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  4. Magobei Yamamoto PhD
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  5. Kazuma Kaku MD
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  6. Tsuneyoshi Yao MD
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  7. Makoto Okumura MD
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Additional information

This work was supported in part by a grant from Clinical Medicine Promoting Foundation, Fukuoka City, Japan.

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Koga, T., Nishida, T., Miwa, H. et al. Effects of dietary butter fat on fecal bile acid excretion in patients with Crohn's disease on elemental diet. Digest Dis Sci 29, 994–999 (1984). https://doi.org/10.1007/BF01311249

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  • DOI: https://doi.org/10.1007/BF01311249

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