Abstract
In an attempt to verify whether the periodicity of ulcer-related symptoms would be confirmed by a spring and fall exacerbation of peptic ulcers, we have analyzed the montly variation of active duodenal ulcers found at endoscopy of the upper gastrointestinal tract in the years 1979–1981. Control diagnoses were active gastric ulcers, gastric and rectal adenocarcinomas, and rheumatoid arthritis. Data were also available on hospital admission for perforated ulcers. The calendar fluctuation of active duodenal ulcer is characterized by a significant fall in August which is associated with July and fall peaks. This pattern of variation for duodenal ulcer was evident in both sexes and across the different decades of age. Duodenal ulcer diagnosis and hospitalization for perforated ulcer fluctuated in a similar way. The shape of monthly variation for active duodenal ulcer was not paralleled by similar changes in gastric ulcers and in the control diagnoses, gastric and rectal carcinomas, and rheumatoid arthritis.
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References
Bockus HL: Diagnosis of uncomplicated chronic peptic ulcers.In Gastroenterology, vol 1, 2nd ed. Philadelphia, WB Saunders, pp. 476–477, 1974
Mizell S: Seasonal variation in gastric hydrochloric acid production inRana pipiens. Am J Physiol 180:650, 1955
Markoc I: Seasonal variations of secretions and acidity of gastric juice in healthy subjects and in dogs. Byull Eksper Biol Med 47:33, 1959
Tzagournis M: Seasonal and monthly incidence of peptic ulcer. JAMA 11:972–975, 1965
Hall WH, Read RC, Wesard L, Lee LE, Robinette CD: The calendar and duodenal ulcer. Gastroenterology 62:1120–1124, 1972
Ahmed SZ, Levine M, Finkbiner RB: The seasonal incidence of complications of peptic ulcer. Ann Intern Med 59:165–171, 1963
Langman MJS: The seasonal incidence of bleeding from the upper gastrointestinal tract. Gut 5:142–144, 1964
Gardiner GC, Pinsky W, Myerson RM: The seasonal incidence of peptic ulcer activity: Fact or fancy? Am J Gastroenterol 45:22–28, 1966
Bodhe YG, Mokashi RY: Seasonal variation in the incidence of peptic ulcer perforations. Int J Biometeorol 19:85–92, 1975
Illingworth CFW, Scott LDW, Jamieson RA: Progress after perforated peptic ulcer. Br Med J 1:787–790, 1946
Hofkin CA: Course of patients with perforated duodenal ulcers. Am J Surg 111:193–196, 1966
Elashoff JD, Grossman MI: Trends in hospital admissions and death rates for peptic ulcer in the United States from 1970 to 1978. Gastroenterology 78:280–285, 1980
Linn HW: Analysis of peptic ulcer in South Australia based on study of 1027 case reports. Med J Aust 2:649–658, 1946
Bodemar G, Walan A: Maintenance treatment of recurrent peptic ulcer by cimetidine. Lancet 1:403–407, 1978
Binder HJ, Grossman MI, McCarthy DM, Bellamy M: Cimetidine, a status report. Curr Prescrib 5:23–41, 1979
Hansky J, Korman MG: Long-term cimetidine in duodenal ulcer disease. Dig Dis Sci 24:465–467, 1979
Kruss DM, Littman A: Safety of cimetidine. Gastroenterology 74:478–483, 1978
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Palmas, F., Andriulli, A., Canepa, G. et al. Monthly fluctuations of active duodenal ulcers. Digest Dis Sci 29, 983–987 (1984). https://doi.org/10.1007/BF01311247
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DOI: https://doi.org/10.1007/BF01311247