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Activation of a type C virus particle in cells from the inbred mouse strain 129/J: Antigenic relationship with the horizontally transmitted type C viruses of primates

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Summary

We have activated a thymus-derived fibroblast cell line from 129/J mice for production of noninfectious type C viral particles. Retroviral particles were produced continuously after cells were treated with ethylnitrosourea, a powerful mutagen and carcinogen. Antigenic analysis of the major structural protein of these particles showed a close relationship with an infectious virus fromMus caroli, a potential progenitor of the horizontally transmitted primate type C viruses. This finding demonstrates the potential of cells from inbred strains ofMus musculus to express upon mutagenesis antigens of theMus caroli class of endogenous MuLV.

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Authors and Affiliations

  1. Laboratory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland, USA

    U. R. Rapp

  2. Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland, USA

    M. Barbacid

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  1. U. R. Rapp
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  2. M. Barbacid
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Rapp, U.R., Barbacid, M. Activation of a type C virus particle in cells from the inbred mouse strain 129/J: Antigenic relationship with the horizontally transmitted type C viruses of primates. Archives of Virology 76, 373–379 (1983). https://doi.org/10.1007/BF01311205

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  • DOI: https://doi.org/10.1007/BF01311205

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