Archives of Virology

, Volume 103, Issue 3–4, pp 253–265 | Cite as

Role of maternal antibody in protection from hemorrhagic fever with renal syndrome virus infection in rats

  • X. -K. Zhang
  • I. Takashima
  • N. Hashimoto
Original Papers

Summary

The effect of maternal antibody on the protection of newborn rats from infection by HFRS virus strain SR-11 was examined. Antibody to HFRS virus was transferred from immune dams to their offspring prenatally as well as postnatally. IgG antibody was detected in the sera of fetuses by IFA test (titers from 1:64 to 1:256) and in fetal fluids (1:32) obtained from the uteri of immune dams at 20 days after mating. In the sera of the newborn, IgG titers of maternal antibody ranged from 1:64 to 1:256 just after birth, reached a peak titer around 1:2,048 at 2 weeks after birth, then declined and disappeared at about 8 weeks of age. No IgA and IgM antibodies were detected in the sera of fetuses and newborns. After intraperitoneal challenge by strain SR-11 (102.2 LD50), death and infection of 2-day-old rats from immune dams were prevented by the presence of maternal antibody. The protective effect of maternal antibody remained in 8-week-old rats having an IFA titer of maternal antibody as low as 1:16, and even in some 10-week-old rats with negative tests for maternal antibody.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Antoniades A, Grekas D, Rossi CA, LeDuc JW (1987) Isolation of a Hatavirus from a severely ill paticnt with hemorrhagic fever with renal syndrome in Greece. J Infect Dis 156: 1010–1013Google Scholar
  2. 2.
    Arikawa J, Takashima I, Hashimato N, Morita C, Sugiyama K, Matsuura Y, Shiga S, Kitamura T (1985) Epidemiological study of hemorrhagic fever with renal syndrome related virus infection among urban rats in two islands in Tokyo Bay, Japan. Acta Virol 29: 66–72Google Scholar
  3. 3.
    Arikawa J, Takashima I, Hashimato N, Takahashi K, Yagi K, Hattori K (1986) Epidemiological studies of hemorrhagic fever with renal syndrome (HFRS) related virus infection among urban rats in Hokkaido, Japan. Arch Virol 88: 231–240Google Scholar
  4. 4.
    Asada H, Tamura M, Kondo K, Okuno Y, Takahashi Y, Dohi Y, Nagai T, Kurata T, Yamanishi K (1987) Role of T lymphocyte subsets in protection and recovery from Hantaan virus infection in mice. J Gen Virol 68: 1961–1969Google Scholar
  5. 5.
    Brummer-Korvenkontio M, Vaheri A, Hovi T, van Bonsdorff C-H, Vuorimies J, Manni T, Penttinen K, Oker-Blom N, Lahdevirta J (1980) Nephropathia epidemica: detection of antigen in bank voles and serologic diagnosis of human infection. J Infect Dis 141: 131–134Google Scholar
  6. 6.
    Childs JE, Korch GW, Glass GE, LeDuc JW, Shah KV (1987) Epizootiology of Hantavirus infections in Baltimore: isolation of a virus from Norway rats, and characteristics in infected rat populations. Am J Epidemiol 126: 55–68Google Scholar
  7. 7.
    Chumakov MP, Gavrilovskaya IN, Boiko VA, Zakharova MA, Myasnikov Yu A, Bashkirev TA, Apekina NS, Safiullin RS, Potapov VS (1981) Detection of hemorrhagic fever with renal syndrome (HFRS) virus in the lungs of Bank volesClethrionomys glareolus and Redbacked volesClethrionomys rutilus trapped in HFRS foci in the European part of U.S.S.R., and serodiagnosis of this infection in man. Arch Virol 69: 295–300Google Scholar
  8. 8.
    Desmyter J, LeDuc JW, Johnson KM, Brasseur F, Deckers C, van Ypersele SC (1983) Laboratory rat associated outbreak of haemorrhagic fever with renal syndrome due to Hantaan-like virus in Belgium. Lancet 2: 1445–1448Google Scholar
  9. 9.
    Dournon E, Moriniere B, Matheron S, Girard PM, Gonzalez JP, Hirsch F, McCormick JB (1984) HFRS after a wild rodent bite in the Haute-Savoie: and risk of exposure to Hantaan-like virus in a Paris laboratory. Lancet 1: 676–677Google Scholar
  10. 10.
    Gronzalez JP, McCormick JB, Baudon D, Gautun JP, Meunier DY, Dournon E, Georges AJ (1984) Serological evidence for Hantaan-related virus in Africa. Lancet 2: 1036–1037Google Scholar
  11. 11.
    Halliday R, Kekwick RA (1961) The selection of antibodies by the gut of the young rat. Proc R Soc Lond [Biol] 153: 279–286Google Scholar
  12. 12.
    Hsu S-M, Raine L (1981) Protein A, avidin, and biotin in immunohistochemistry. J Histochem Cytochem 29: 1349–1353Google Scholar
  13. 13.
    Jordan SM, Morgan EH (1967) Albumin, transferrin and gamma-globulin metabolism during lactation in the rat. Quart J Exp Physiol 52: 422–429Google Scholar
  14. 14.
    Jordan SM, Morgan EH (1968) The development of selectivity of protein absorption from the intestine during suckling in the rat. Aust J Exp Biol Med Sci 46: 465–472Google Scholar
  15. 15.
    Kitamura T, Morita C, Komatsu T, Sugiyama K, Arikawa J, Shiga S, Takeda H, Akao Y, Imaizumi K, Oya A, Hashimoto N, Urasawa S (1983) Isolation of virus causing hemorrhagic fever with renal syndrome (HFRS) through a cell culture system. Jap J Med Sci Biol 36: 17–25Google Scholar
  16. 16.
    LeDuc JW, Smith GA, Childs JE, Pinheiro FP, Naiztegui JI, Miklasson B, Antoniades A, Robinson DM, Khin M, Shortridge KF, Wooster MT, Elwell MR, Libery PLT, Koech D, Rosa EST, Rosen L (1986) Global survey of antibody to Hantaan-related viruses among peridomestic rodents. Bull WHO 64: 139–144Google Scholar
  17. 17.
    LeDuc JW, Smith GA, Pinheiro FP, Vasconcelos PFC, Rosa EST, Maiztegui JI (1985) Isolation of a Hantaan-related virus from Brazilian rats and serologic evidence of its widespread distribution in South America. Am J Trop Med Hyg 34: 810–815Google Scholar
  18. 18.
    Lee HW, Lee PW, Johnson KM (1978) Isolation of the etiologic agent of Korean hemorrhagic fever. J Infect Dis 137: 298–308Google Scholar
  19. 19.
    Lee HW, Seong IW, Baek LJ, Mcleod DA, Seo JS, Kang CY (1984) Positive serological evidence that Hantaan virus, the etiologic agent of hemorrhagic fever with renal syndrome, in endemic in Canada. Can J Microbiol 30: 1137–1140Google Scholar
  20. 20.
    Lloyd G, Bowen ETW, Jones N, Pendry A (1984) HFRS outbreak associated with laboratory rats in UK. Lancet 1: 1175–1176Google Scholar
  21. 21.
    Morita CH, Matsuura Y, Morikawa SH, Kitamura T (1985) Age-dependent transmission of hemorrhagic fever with renal syndrome (HFRS) virus in rats. Arch Virol 85: 145–149Google Scholar
  22. 22.
    Morita C, Morikawa S, Iida A, Ogata M, Sugiyama K, Kitamura T (1986) Protective role of passive administration of antibody against HFRS. JE HFRS Bull WHO 1: 69Google Scholar
  23. 23.
    Nagai T, Tanishita O, Takahashi Y, Yamanouchi T, Domae K, Kondo K, Dantas JR, Jr, Takahashi M, Yamanishi K (1985) Isolation of haemorrhagic fever with renal syndrome virus from leukocytes of rats and virus replication in cultures of rat and human macrophages. J Gen Virol 66: 1271–1278Google Scholar
  24. 24.
    Nakamura T, Yanagihara R, Gibbs CJ, Gajdusek DC (1985) Immune spleen cellmediated protection against fatal Hantaan virus infection in infant mice. J Infect Dis 151: 691–697Google Scholar
  25. 25.
    Simpson-Morgan MW, Smeaton TC (1972) The transfer of antibodies by neonates and adults. Adv Vet Sci Comp Med 16: 355–386Google Scholar
  26. 26.
    Song G, Hang C-S, Qui X-Z, Ni D-S, Liao H-X, Gao G-Z, Du Y-L, Xu J-K, Wu Y-S, Zhao J-N, Kong B-X, Wang Z-S, Zhang Z-Q, Shen H-K, Zhou N (1983) Etiologic studies of epidemic hemorrhagic fever (hemorrhagic fever with renal syndrome). J Infect Dis 147: 654–659Google Scholar
  27. 27.
    Stechschulte DJ, Austen KF (1970) Immunoglobulins of rat colostrum. J Immunol 104: 1052–1062Google Scholar
  28. 28.
    Tamura M (1964) Occurrence of epidemic hemorrhagic fever in Osaka city: first cases found in Japan with characteristic feature of marked proteinuria. Biken J 7: 79–94Google Scholar
  29. 29.
    Tanishita O, Takahashi Y, Okuno Y, Yamanishi K, Takahashi M (1984) Evaluation of focus reduction neutralization test with peroxidase-antiperoxidase staining technique for hemorrhagic fever with renal syndrome virus. J Clin Microbiol 20: 1213–1215Google Scholar
  30. 30.
    Tanishita O, Takahashi Y, Okuno Y, Tamura M, Asada H, Dantas JR, Jr, Yamanouchi T, Domae K, Kurata T, Yamanishi K (1986) Persistent infection of rats with haemorrhagic fever with renal syndrome virus and their antibody responses. J Gen Virol 67: 2819–2824Google Scholar
  31. 31.
    Tze-Wai W, Cheong CY, Lee HW (1986) Haemorrhagic fever with renal syndrome: a Singapore case. JE HFRS Bull WHO 1: 51Google Scholar
  32. 32.
    Verhagen R, Leirs H, Tkachenko E, van der Groen G (1986) Ecological and epidemiological data on Hantavirus in bank vole populations in Belgium. Arch Virol 91: 193–205Google Scholar
  33. 33.
    Wah LT, Mangalam S, Lee HW (1987) Hemorrhagic fever with renal syndrome: report of a case in Malaysia. J Infect Dis 156: 1035–1036Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • X. -K. Zhang
    • 1
  • I. Takashima
    • 1
  • N. Hashimoto
    • 1
  1. 1.Department of Veterinary Public Health, Faculty of Veterinary MedicineHokkaido UniversitySapporoJapan

Personalised recommendations