Summary
Selective uptake of the cerebral blood-flow imaging agent99mTc-hexamethylpropyleneamine oxime (HM-PAO) by Human Herpesvirus 1 (HSV-1) infected cells was investigated in vivo and in vitro. No specific uptake of HM-PAO was observed either in encephalitic rats (by brain scintigraphic imaging or by immunoperoxidase staining/autoradiography of brain sections) or in HSV-1 infected Vero cells.
This is a preview of subscription content, log in via an institution to check access.
References
Bligh AS, Weaver CM, Wells CEC (1972) Isotope encephalography in the management of acute herpesvirus encephalitis. J Neurol Neurosurg Psychiatry 35: 569–581
Cleator GM, Klapper PE, Lewis AG, Sharma HL, Longson M (1988) Specific neuroradiological diagnosis of herpes encephalitis in an animal model. Arch Virol 101: 1–12
Cleator GM, Klapper PE, Sharma H, Longson M (1987) A rat model of herpes encephalitis with special reference to its potential for the development of diagnostic brain imaging. J Neurol Sci 79: 55–66
Deschamps J, DeClerq E (1981) Specific phosphorylation of E-(5)-(2-idovinyl)-2′-deoxyuridine by herpes simplex infected cells. J Biol Chem 256: 5973–5976
Fishman RA (1987) No, brain biopsy need not be done in every patient suspected of having herpes simplex encephalitis. Arch Neurol 44: 1291–1292
Hanley DF, Johnson RT, Whitley RD (1987) Yes, brain biopsy should be a prerequisite for herpes simplex encephalitis treatment. Arch Neurol 44: 1289–1290
Klapper PE, Cleator GM, Bruce JM, Longson M (1988) Penetration of the blood-brain barrier by the antiviral drug (E)-5-(2-iodovinyl)-2′-deoxyuridine in a rat model of herpes encephalitis. Drug Design Deliv 3: 57–68
Klapper PE, Cleator GM, Lewis AG (1988)99mTc-HMPAO scanning in focal encephalitis. Lancet ii: 105
Launes J, Nikkinen P, Lindroth L, Brownell A-L, Liewendahl K, Iivanainen M (1988) Diagnosis of acute herpes simplex encephalitis by brain perfusion single photon emission computed tomography. Lancet i: 1188–1191
Lear JL (1988) Quantitative local cerebral blood flow measurements with Technetium-99m HM-PAO: evaluation using multiple radionuclide digital quantitative autoradiography. J Nucl Med 29: 1387–1392
Lewis AG, Klapper PE, Cleator GM, Templeton PP, Longson M (1989) Altered in vitro uptake of (E)-5-(2-125Iodovinyl)-2′-deoxyuridine following administration of the antineoplastic agent etoposide. Res Virol 140: 7–13
Price RW, Saito Y, Fox JJ (1983) Prospects for the use of radiolabelled antiviral drugs in the diagnosis of herpes simplex encephalitis. Biochem Pharmacol 32: 2455–2461
Saito Y, Price RW, Rottenberg DA, Fox JJ, Su TL, Watanabe KA, Phillips FS (1982) Quantitative autoradiographic mapping of herpes simplex virus encephalitis with a radio-labeled antiviral drug. Science 217: 1151–1153
Whitley RF, Alford CA, Hirsch MS, Schooley RT, Luby JP, Aoki FY, Hanley D, Nahmias AJ, Soong SJ (1986) Vidarabine versus acyclovir therapy in herpes simplex encephalitis. N Engl J Med 314: 144–149
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cleator, G.M., Lewis, A.G., Klapper, P.E. et al. HM-PAO-imaging and herpes encephalitis. Archives of Virology 109, 263–268 (1989). https://doi.org/10.1007/BF01311086
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01311086