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Hydrolysis of inositol lipids: an early signal of human cytomegalovirus infection

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Summary

The production of inositol 1,4,5-triphosphate (IP 3) and 1,2-diacylglycerol (DG) as an early cellular response to human cytomegalovirus (HCMV) infection was investigated in human embryo lung (LU) cells. The results obtained show transient 85 and 30% increases in IP3 and DG, respectively, 20 min post-exposure to HCMV. Following heat inactivation or serum neutralization of HCMV stock or in the presence of papaverine we failed to detect increased levels of IP3 and DG relative to mock-infected LU cultures.

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Author notes

  1. T. Valyi-Nagy

    Present address: Department of Dermatology, Semmelweis Medical School, H-1085, Budapest, Hungary

  2. I. Boldogh

    Present address: Institute of Microbiology, Medical University of Debrecen, H-4012, Hungary

Authors and Affiliations

  1. Department of Microbiology, The University of Texas Medical Branch, Galveston, Texas, USA

    T. Valyi-Nagy, I. Boldogh & T. Albrecht

  2. Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA

    Z. Bandi

Authors
  1. T. Valyi-Nagy
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  2. Z. Bandi
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  3. I. Boldogh
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  4. T. Albrecht
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Valyi-Nagy, T., Bandi, Z., Boldogh, I. et al. Hydrolysis of inositol lipids: an early signal of human cytomegalovirus infection. Archives of Virology 101, 199–207 (1988). https://doi.org/10.1007/BF01311001

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  • DOI: https://doi.org/10.1007/BF01311001

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