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The capsid protein-encoding sequence of foot-and-mouth disease virus O2Brescia

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Summary

Nucleotide sequences encoding the four capsid proteins of foot-and-mouth disease virus subtype O2Brescia/1947 have been determined. These and the deduced amino acid sequences were compared with those of a subtype O1 virus strain. The nucleotide sequences differed at 259 positions, causing only 35 amino acid changes. VP 4 and VP 2 differed by 2.4 and 1.8%, whereas VP 1, known as major viral antigen, and VP 3 differed by 8% and 5.5%, respectively. The differences occur mainly in protein domains not involved in the formation of α-helices and β-sheets, suggesting that the surfaces of both viruses are more variable than their scaffolds. The O2Brescia sequence has been submitted to the GenBank data base and has the accession number M 55287.

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Authors and Affiliations

  1. Federal Research Centre for Virus Diseases of Animals, Tübingen, Germany

    O. Krebs & O. Marquardt

  2. Friedrich Miescher Laboratory of the Max-Planck-Society, Tübingen, Germany

    H. G. Berger

Authors
  1. O. Krebs
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  2. H. G. Berger
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  3. O. Marquardt
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Krebs, O., Berger, H.G. & Marquardt, O. The capsid protein-encoding sequence of foot-and-mouth disease virus O2Brescia. Archives of Virology 120, 135–143 (1991). https://doi.org/10.1007/BF01310956

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  • DOI: https://doi.org/10.1007/BF01310956

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