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Genetic relatedness of virulent and avirulent strains of Marek's disease virus

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Summary

Comparative studies using Southern blot hybridization indicated that the avirulent strains of Marek's disease virus (MDV) were probably generated through DNA rearrangement that occurred in the limited area(s) of the virulent MDV genome.

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References

  1. Chang, A. C. Y., Cohen, S. N.: Construction and characterization of amplifiable multicopy DNA cloning vehicle derived from the P15A cryptic miniplasmid. J. Bacteriol.134, 1141–1156 (1978).

    Google Scholar 

  2. Churchill, A. E., Baxendale, W.: The attenuation, with loss of oncogenicity, of the herpes-type virus of Marek's disease (strain HPRS-16) on passage in cell culture. J. gen. Virol.4, 557–564 (1969).

    Google Scholar 

  3. Given, D., Kieff, E.: DNA of Epstein-Barr virus. IV. Linkage map of restriction enzyme fragments of the B 95-8 and W91 strains of Epstein-Barr virus. J. Virol.28, 524–542 (1978).

    Google Scholar 

  4. Hirai, K., Ikuta, K., Kato, S.: Comparative studies on Marek's disease virus and herpesvirus of turkey DNAs. J. gen. Virol.45, 119–131 (1979).

    Google Scholar 

  5. Hirai, K., Ikuta, K., Kato, S.: Structural changes of the DNA of Marek's disease virus during serial passage in cultured cells. Virology115, 385–389 (1981).

    Google Scholar 

  6. Hirai, K., Ikuta, K., Kato, S.: Restriction endonuclease analysis of the genomes of virulent and avirulent Marek's disease viruses. Microbiol. Immunol.25, 671–681 (1981).

    Google Scholar 

  7. Nazerian, K.: Attenuation of Marek's disease virus and study of its properties in two different cell cultures. J. Natl. Cancer Inst.44, 1257–1267 (1970).

    Google Scholar 

  8. Purchase, H. G., Burmester, B. R., Cunningham, C. H.: Pathogenicity and antigenicity of clones from strains of Marek's disease virus and the herpesvirus of turkeys. Infect. Immun.3, 295–303 (1971).

    Google Scholar 

  9. Skare, J., Strominger, J. L.: Cloning and mapping of BamHI endonuclease fragments of DNA from the transforming B95-8 strain of Epstein-Barr virus. Proc. Natl. Acad. Sci. U.S.A.77, 3860–3864 (1980).

    Google Scholar 

  10. Southern, E. M.: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol.98, 503–517 (1975).

    Google Scholar 

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Authors and Affiliations

  1. Department of Molecular Biology, Tokai University School of Medicine, Bohesidai, Isehara, Japan

    K. Hirai

  2. Department of Pathology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

    H. Honma, K. Ikuta & S. Kato

Authors
  1. K. Hirai
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  2. H. Honma
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  3. K. Ikuta
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  4. S. Kato
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Hirai, K., Honma, H., Ikuta, K. et al. Genetic relatedness of virulent and avirulent strains of Marek's disease virus. Archives of Virology 79, 293–298 (1984). https://doi.org/10.1007/BF01310818

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  • DOI: https://doi.org/10.1007/BF01310818

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